Exploring New Treatments for Persistent Smell Disorders - Otolaryngology

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Olfactory issues


Two years ago, I had a severe cold (or allergy), and although I recovered, I lost my sense of smell.
After treatment from a physician at Taichung Veterans General Hospital, there has been no improvement until now.
Are there any new treatment options available?

Wang Xiansheng, 30~39 year old female. Ask Date: 2020/04/29

Dr. Ji Zhaoyun reply Otolaryngology


Hello, there are many possible causes for olfactory dysfunction.
Depending on the situation, examinations such as nasal endoscopy, computed tomography (CT), olfactory testing (which should have specialized equipment at Taichung Veterans General Hospital), and olfactory nerve assessments may be conducted.
Based on the results of these tests, different medication treatment recommendations may be provided.
If symptoms persist, you can consult your primary physician for further discussion and long-term treatment options.
Wishing you peace and good health.

Reply Date: 2020/04/29

More Info


Persistent smell disorders, particularly anosmia (the complete loss of smell) and hyposmia (reduced ability to smell), can be quite distressing and significantly impact quality of life. These conditions can arise from various causes, including viral infections like the flu or COVID-19, head trauma, nasal obstructions, or chronic sinusitis. Given your history of severe cold and subsequent loss of smell, it is likely that your condition is related to the initial viral infection or an underlying nasal issue.

Recent advancements in the treatment of smell disorders have focused on several approaches, including olfactory training, pharmacological treatments, and surgical interventions. Here’s a detailed overview of these options:
1. Olfactory Training: This is a non-invasive method that involves repeated exposure to specific scents over a period of time. The goal is to stimulate the olfactory system and promote recovery of smell function. Patients typically use essential oils or familiar scents (like rose, lemon, clove, and eucalyptus) and smell them twice daily for several months. Studies have shown that olfactory training can be beneficial, especially for individuals who have lost their sense of smell due to viral infections.

2. Pharmacological Treatments: While there is no specific medication approved solely for the treatment of smell disorders, some treatments may help manage underlying conditions. For example, corticosteroids can reduce inflammation in the nasal passages, which may improve smell function if there is an obstruction or inflammation present. Other medications, such as antihistamines or decongestants, may be prescribed if allergies or nasal congestion are contributing factors.

3. Surgical Interventions: In cases where structural issues, such as a deviated septum or nasal polyps, are causing smell disorders, surgical options may be considered. Procedures like septoplasty (to correct a deviated septum) or polypectomy (to remove nasal polyps) can help restore normal airflow and improve olfactory function.

4. Emerging Therapies: Research is ongoing into new treatments for smell disorders. Some studies are exploring the use of neuroprotective agents that may help repair damaged olfactory neurons. Additionally, there is interest in the role of olfactory stem cells and their potential to regenerate olfactory function.

5. Lifestyle Modifications: Maintaining good nasal hygiene, avoiding irritants (like smoke or strong odors), and managing allergies can also play a role in improving smell function. Staying hydrated and using saline nasal sprays may help keep the nasal passages clear.

If you have not seen significant improvement after your treatment at Taichung Veterans General Hospital, it may be worthwhile to consult with an otolaryngologist (ENT specialist) who specializes in smell disorders. They can provide a comprehensive evaluation, including imaging studies if necessary, to determine if there are any underlying issues that need to be addressed.

In conclusion, while persistent smell disorders can be challenging, there are various treatment options available. Olfactory training, pharmacological treatments, and surgical interventions are all potential avenues to explore. It’s essential to work closely with a healthcare provider to determine the most appropriate course of action based on your specific situation. With patience and the right approach, many individuals experience improvement in their sense of smell over time.

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