Medication Interactions in Urology: Urief and Solifenacin - Urology

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Drug interaction issues


Hello Doctor, I have a few questions regarding my treatment.
I have been diagnosed with chronic prostatitis and visited a urology clinic where I was prescribed Urief.
During my last follow-up, I mentioned experiencing frequent urination, and the clinic prescribed me Solifenacin.
Here are my questions:
1) Urief is supposed to help me urinate better, while Solifenacin is intended to reduce my frequency of urination.
Won't these two medications conflict with each other? Shouldn't I just stop taking Urief?
2) Is it possible that Solifenacin could cause me to have difficulty urinating? If so, what should I do about it?
3) Can anti-anxiety medications cause frequent urination?

Niming, 20~29 year old female. Ask Date: 2020/05/30

Dr. Du Shixi reply Urology


Hello: 1) The main function of the two is to be used in different areas; many physicians use them this way, and they should be considered complementary, so there’s no need to worry.
2) No, the chances of this happening are very rare; it’s more important to maintain a normal lifestyle.
3) It depends on the type of medication; most medications have a package insert for reference, and you can also find information online.
If you have any questions, feel free to provide them to me, and I will look them up.
Wishing you good health.

Reply Date: 2020/05/30

More Info


When it comes to understanding medication interactions, particularly in the context of urology, it is essential to consider how different medications can work together or potentially conflict with one another. In your case, you are taking Urief (which contains the active ingredient mirabegron) and Solifenacin, both of which are used to manage urinary symptoms but have different mechanisms of action.

1. Interaction Between Urief and Solifenacin: Urief is primarily used to treat overactive bladder symptoms by relaxing the bladder muscle, which helps you urinate more effectively. On the other hand, Solifenacin is an anticholinergic medication that reduces bladder contractions, thereby helping to decrease urinary frequency and urgency. While it may seem that these two medications could conflict, they are often used together in clinical practice to provide a more comprehensive approach to managing urinary symptoms. The rationale behind this combination is that Urief can help improve bladder emptying, while Solifenacin can help manage the frequency of urination. Therefore, it is not necessarily advisable to stop taking Urief just because you are also on Solifenacin; rather, they can complement each other.

2. Risk of Urinary Retention with Solifenacin: One concern with anticholinergic medications like Solifenacin is the potential for urinary retention, which is the inability to completely empty the bladder. However, this side effect is relatively uncommon, especially when the medication is used at the recommended doses. If you experience difficulty urinating or feel that you cannot empty your bladder completely, it is crucial to contact your healthcare provider immediately. They may need to evaluate your symptoms and possibly adjust your medication regimen. It’s important to maintain open communication with your doctor about any side effects you experience.

3. Antianxiety Medications and Urinary Frequency: Regarding your question about antianxiety medications and their potential to cause urinary frequency, it is important to note that different classes of medications can have varying effects on urinary function. Some antianxiety medications may lead to increased urinary frequency as a side effect, while others may not. For instance, benzodiazepines can sometimes cause sedation and relaxation of the bladder, which might lead to increased urination. However, this effect can vary widely among individuals. If you are taking an antianxiety medication and notice changes in your urinary habits, it would be wise to discuss this with your healthcare provider to determine if any adjustments are necessary.

In summary, while Urief and Solifenacin may seem to have opposing effects, they can actually work together to manage urinary symptoms effectively. It is essential to monitor for any side effects, particularly with Solifenacin, and to maintain communication with your healthcare provider regarding any concerns, including the effects of other medications you may be taking. Always consult your doctor before making any changes to your medication regimen, as they can provide personalized advice based on your specific health needs and circumstances.

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