Dryness Syndrome: Insights from ENT Specialists - Otolaryngology

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Sjögren's syndrome issues?


Hello, I had a check-up a week ago due to concerns about Sjögren's syndrome (I described my situation to the doctor: I have experienced dry mouth 3 to 4 times in the past two years, each episode lasting about 3 to 4 weeks, with varying severity on different days; it is usually accompanied by gastric ulcers; dry eyes are not significant.
The doctor said it doesn't seem like Sjögren's but suggested testing anyway).
Today I reviewed the report (five vials of blood were drawn; among them, there was a test for anti-SSA/Ro antibodies, and I am not sure about the others; the doctor mentioned checking for related complications).
The results were reported as very normal (with values less than 10 and less than 12, and no complications).
When I asked if I should undergo a salivary gland biopsy, I followed his advice: to observe myself for now, as it does not affect my daily life.
Does the doctor think this approach is appropriate? Note: I have previously been tested for diabetes, liver, and kidney function, all of which were normal.

Daxuesheng, 20~29 year old female. Ask Date: 2020/06/03

Dr. Zheng Jueyi reply Otolaryngology


Hello, if the indices are normal and there are no obvious symptoms, you may start with self-observation.
If you have concerns, you can regularly follow up at the rheumatology and immunology outpatient clinic or visit the otolaryngology department for a biopsy confirmation.
Wishing you peace and health.
Sincerely, Dr.
Cheng Jue-Yi, Director of the Department of Otolaryngology, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2020/06/03

More Info


Understanding Dryness Syndrome, particularly in the context of conditions like Sjögren's syndrome, is crucial for both patients and healthcare providers. Your experience with recurrent episodes of dry mouth and the accompanying symptoms raises important questions about the underlying causes and the appropriate management strategies.

Dryness syndrome, often characterized by xerostomia (dry mouth) and xerophthalmia (dry eyes), can be a manifestation of several conditions, with Sjögren's syndrome being one of the most common autoimmune disorders associated with these symptoms. Sjögren's syndrome primarily affects the exocrine glands, leading to decreased saliva and tear production. However, it can also have systemic implications, affecting other organs and leading to complications such as fatigue, joint pain, and even increased risk of lymphoma.

In your case, the intermittent nature of your symptoms over the past two years, along with the association with gastric ulcers, suggests that there may be multiple factors at play. The fact that your blood tests returned normal results, particularly regarding the specific autoantibodies typically associated with Sjögren's syndrome (like anti-Ro/SSA and anti-La/SSB), is reassuring. Normal results in these tests often indicate that an autoimmune process is less likely, but it does not completely rule out the possibility of a mild or early form of the syndrome.

The recommendation from your physician to monitor your symptoms rather than immediately proceeding with a salivary gland biopsy is a reasonable approach, especially since the biopsy is an invasive procedure and may not provide additional useful information if your symptoms are not significantly impacting your quality of life. It's essential to weigh the risks and benefits of such procedures, and your physician's suggestion to observe and report any changes is prudent.

In terms of management, there are several strategies you might consider to alleviate your symptoms. Staying hydrated, using saliva substitutes, and employing humidifiers at home can help manage dry mouth. For dry eyes, artificial tears and punctal plugs may provide relief. Additionally, addressing any underlying conditions, such as managing gastric ulcers, is crucial as they can contribute to your overall health and symptomatology.

It's also worth noting that lifestyle factors, including diet, stress management, and regular check-ups, play a significant role in managing chronic conditions. If your symptoms worsen or new symptoms arise, it would be wise to revisit your healthcare provider for further evaluation.

In summary, while your current situation does not strongly indicate a severe underlying condition, continued observation and symptom management are key. Should your symptoms persist or escalate, further diagnostic measures, including imaging studies or more specific blood tests, may be warranted. Always feel empowered to discuss any concerns with your healthcare provider, as they can offer tailored advice based on your unique health profile.

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