Blood in Urine After Gonorrhea Treatment: Causes and Concerns - Urology

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Hematuria after the treatment of gonorrhea?


Doctor, I fell ill at the end of February.
Initially, the doctor treated me for Chlamydia, but I felt something was off (I experienced lower back spasms and anal burning during sleep).
In early April, I switched to a second doctor who diagnosed me with gonorrhea and administered an injection.
My condition has improved since then, but in mid-March, the doctor mentioned there was occult blood in my urine, which was likely caused by the gonorrhea, though I didn't think much of it.
(Subsequently, I underwent anonymous testing for HIV and syphilis at National Taiwan University Hospital in January and March, both of which were negative.)
Initially, I had occult blood, which progressed to painless hematuria after jogging, and now I have gross painless hematuria along with a sensation of incomplete bladder emptying.
I consulted a doctor again, and the urinalysis showed a significant amount of red blood cells, while X-rays and CT scans (with contrast) were normal.
I am currently scheduled for a cystoscopy.
What could be the cause of this? The urinalysis did not show any casts, which suggests that the bleeding is not from the kidneys.
I read online that syphilis could potentially cause hematuria, but I currently have no other symptoms of syphilis.
I'm really worried that the hematuria might be caused by syphilis...

Li Sir, 30~39 year old female. Ask Date: 2020/06/09

Dr. Du Shixi reply Urology


Hello: Your symptoms are likely not related to a sexually transmitted infection.
A blood test for syphilis can determine if it is present.
The cause of hematuria needs further examination to confirm.
There is also a high percentage of cases where a definitive cause cannot be found, and a cystoscopy may be necessary for evaluation.
Painless hematuria after jogging could be exercise-induced hematuria, so it's important to be cautious with exercise and avoid sudden increases in activity level and intensity.
Wishing you good health.

Reply Date: 2020/06/09

More Info


Blood in urine, or hematuria, can be a concerning symptom, especially following a diagnosis and treatment for sexually transmitted infections (STIs) like gonorrhea. Your situation involves a complex interplay of factors that could be contributing to your symptoms. Let's break down the potential causes and concerns regarding your condition.

First, it’s important to understand that hematuria can arise from various sources within the urinary tract, including the kidneys, ureters, bladder, and urethra. Given your history of gonorrhea, it’s essential to consider how this infection and its treatment may relate to your current symptoms.

1. Infection and Inflammation: Gonorrhea can cause inflammation in the urinary tract, which may lead to irritation and bleeding. Even after treatment, residual inflammation could persist, potentially resulting in hematuria. Additionally, if there was any co-infection with other pathogens, this could complicate the clinical picture.

2. Urinary Tract Injury: The treatment for gonorrhea often involves antibiotics, which typically do not cause hematuria directly. However, if there was any manipulation during examinations or treatments (like catheterization), it could lead to trauma in the urinary tract, resulting in bleeding.

3. Kidney Stones or Other Urological Issues: The symptoms you describe, such as back pain and a burning sensation, could also suggest the presence of kidney stones or other urological conditions. Stones can cause irritation and bleeding as they pass through the urinary tract, leading to hematuria.

4. Bladder or Kidney Conditions: The fact that you have undergone imaging studies (X-ray and CT scan) that returned normal results is reassuring, but it does not entirely rule out conditions such as interstitial cystitis or bladder inflammation. A cystoscopy (bladder scope) can provide direct visualization of the bladder lining and help identify any abnormalities.

5. Other Infections: While you mentioned that you tested negative for HIV and syphilis, other infections could still be at play. For instance, a urinary tract infection (UTI) could cause hematuria and might not always present with typical symptoms.
6. Coagulation Disorders: Although less common, bleeding disorders could also lead to hematuria. If you have any family history of bleeding disorders or if you are on any medications that affect blood clotting, this should be discussed with your healthcare provider.

Regarding your concern about syphilis causing blood in urine, while syphilis can lead to various systemic complications, it is less commonly associated with hematuria unless there are significant complications. The absence of other symptoms typically associated with syphilis is a good sign.

In summary, while your symptoms may be alarming, it is crucial to approach this systematically. The upcoming cystoscopy will be an important step in determining the cause of your hematuria. It is also advisable to keep an open line of communication with your healthcare provider, discussing any new symptoms or concerns as they arise. If you experience any additional symptoms such as fever, chills, or worsening pain, seek medical attention promptly.
Lastly, maintaining a healthy lifestyle, staying hydrated, and avoiding irritants (like caffeine and alcohol) can support urinary tract health. It’s essential to follow up with your healthcare provider to ensure a thorough evaluation and appropriate management of your symptoms.

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