Withdrawal symptoms from Yuankang?
Hello Dr.
Wang,
I have been taking medication for depression for about 10 years.
Initially, I was on a heavy regimen with multiple medications, but over time, I gradually reduced it to just taking Wellbutrin (Bupropion).
About six months ago, after discussing with my doctor, I reduced my dosage from 75 mg twice a day to 75 mg once a day.
During the reduction, I experienced symptoms similar to having a fever, with body aches, vomiting, nausea, and cramps.
My mood became irritable, but I managed to endure it, and it took almost a month to recover.
Starting last week, I stopped taking the last 75 mg of Wellbutrin daily (after discussing with my doctor, who mentioned I might feel uncomfortable but believed my condition had improved over the past two years and encouraged me to try).
After stopping, I began to feel strange in my ears, dizzy, and had headaches, along with palpitations and chest tightness.
My mood has also been quite irritable, but I can tolerate it because of my previous experience, knowing that if I endure this period, it will pass.
However, what frightens me is that I sometimes suddenly find it difficult to think or understand written text.
For example, while reading an article, I can understand each word, but when they form a sentence, I cannot grasp its meaning.
I also struggle to connect the meaning of one sentence to the next, making it hard to comprehend what the article is about.
I know it’s not that the article is complex; even when I read something I have gone through countless times, I still cannot understand it.
This situation does not occur continuously; sometimes, after a good night's sleep, I return to normal, but at other times, I suddenly cannot comprehend anything.
Another issue I have encountered is that when I try to send messages to others, I think of normal sentences in my mind, but what I type comes out completely different and often illogical.
I have deleted and retyped messages multiple times, but I cannot seem to type what I intend; instead, I end up with a jumble of nonsensical words.
Again, this happens suddenly and then returns to normal.
Today, I experienced something that worried me the most.
While riding my bike on a route I take every day to work, I suddenly felt something was off.
Although I could see the correct road, I felt as if it was wrong.
After riding a short distance, I suddenly didn’t know how to proceed or remember how to get to a place I go to daily and enjoy.
I stopped by the roadside for a moment to think but couldn’t recall.
Just as I was about to call for help, everything suddenly returned to normal, and my thoughts and memory came back, allowing me to reach my office successfully.
I wonder if these symptoms are part of withdrawal from the medication? I feel a bit worried and scared because this seems different from physical symptoms that I can endure.
I am also unsure if it could worsen or lead to something more serious.
Therefore, I am asking for your clarification.
Thank you very much!
Ms. Lin, 30~39 year old female. Ask Date: 2020/06/18
Dr. Wang Yaoting reply Psychiatry
The mechanism of action of "Yuekang 75mg" is to enhance the effects of central serotonin and norepinephrine.
Withdrawal symptoms may occur upon discontinuation of the medication, such as dizziness, nausea, fatigue, and headaches.
There have also been case reports of symptoms including memory impairment, difficulty concentrating, balance issues, sensory disturbances, and impulsive behavior.
The duration of these symptoms can range from several days to several months, with reports indicating that withdrawal symptoms generally become milder over time.
If the symptoms do not cause significant discomfort or disruption to daily life, monitoring may continue.
However, if symptoms progressively worsen, it is advisable to return to the clinic to discuss with a physician whether a short-term adjustment of the medication or further medical evaluations are necessary.
I hope this answers your question.
:)
Reply Date: 2020/06/18
More Info
Hello! Thank you for sharing your experiences and concerns regarding the withdrawal symptoms from your antidepressant medication. It’s commendable that you are actively seeking to understand what you are going through, and I hope to provide some clarity on your situation.
First, it’s important to recognize that withdrawal symptoms can occur when discontinuing or reducing the dosage of antidepressants, particularly those in the class of selective serotonin reuptake inhibitors (SSRIs) like Venlafaxine (Effexor). These symptoms can vary widely among individuals and may include physical symptoms such as flu-like feelings, headaches, dizziness, nausea, and emotional symptoms like irritability and mood swings. The symptoms you described, such as body aches, vomiting, and emotional volatility, are consistent with what many patients experience during withdrawal.
The cognitive symptoms you mentioned, such as difficulty understanding text or forming coherent sentences, can also be associated with withdrawal. This phenomenon is sometimes referred to as "brain fog," and it can manifest as a temporary inability to concentrate or process information effectively. These cognitive disturbances can be alarming, especially when they interfere with daily activities like driving or working. However, it’s crucial to remember that these symptoms are often temporary and may improve as your body adjusts to the absence of the medication.
Your experience of suddenly feeling lost while riding a familiar route is particularly concerning, but it can also be attributed to the cognitive effects of withdrawal. This disorientation can be distressing, but it’s essential to approach it with caution. If these episodes become more frequent or severe, it would be wise to consult your healthcare provider. They can assess your symptoms and determine whether they are indeed related to withdrawal or if there may be another underlying issue that needs to be addressed.
Given that you have been on antidepressants for a decade, it’s understandable that your body may take time to readjust after reducing or stopping medication. The brain's neurochemistry can take time to stabilize, and during this period, fluctuations in mood, cognition, and physical sensations can occur. It’s also worth noting that some individuals may experience a resurgence of depressive or anxious symptoms during withdrawal, which can complicate the overall experience.
In terms of managing these withdrawal symptoms, it’s crucial to maintain open communication with your healthcare provider. They may suggest a more gradual tapering schedule or provide additional support, such as therapy or temporary medications to help ease the transition. It’s also beneficial to engage in self-care practices, such as regular exercise, a balanced diet, and mindfulness techniques, which can help mitigate some of the emotional and cognitive symptoms you are experiencing.
Lastly, while it’s natural to feel anxious about these symptoms, try to remind yourself that many people have successfully navigated the withdrawal process and have gone on to feel better without medication. Recovery is often a journey that requires patience and support, so don’t hesitate to reach out to your healthcare team for guidance and reassurance.
In summary, the symptoms you are experiencing could very well be related to the withdrawal from your antidepressant medication. While they can be uncomfortable and concerning, they are often temporary. Maintaining communication with your healthcare provider and employing self-care strategies can help you navigate this challenging period. Remember, you are not alone in this journey, and support is available to help you through it. Wishing you strength and clarity as you move forward!
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