Lung Abnormalities: Is It Really Tuberculosis? - Pulmonology

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Abnormalities in the lungs?


Hello Doctor: Last month, I had a physical examination, and the chest X-ray showed an abnormality with a small dark shadow in the lungs.
The doctor suspected it might be tuberculosis, so I underwent a CT scan and sputum tests.
However, all three sputum test results came back negative, but the CT scan still showed the abnormal dark shadow.
The doctor mentioned it could still be tuberculosis and issued a certificate stating that the lung examination is consistent with tuberculosis lesions, prescribing a six-month course of medication.
However, I would like to ask, if all three sputum tests are negative and I have no other symptoms, could it still be tuberculosis? Is it accurate for the doctor to diagnose based solely on the CT scan results? I am concerned about a potential misdiagnosis and do not want to take medication for six months due to the possible harm to my body.
Can I go to another hospital for a re-evaluation?

Candy, 30~39 year old female. Ask Date: 2020/06/18

Dr. Zhou Ziguang reply Pulmonology


Hello: Based on the findings, the chest X-ray and chest CT scan show imaging characteristics consistent with tuberculosis.
A negative sputum smear indicates that there is currently no evidence of infectiousness, but it does not completely rule out the possibility of tuberculosis.
The physician has made a clinical diagnosis of tuberculosis and will continue to monitor the clinical condition.
Please discuss further with your physician.

Reply Date: 2020/06/18

More Info


When it comes to lung abnormalities, especially concerning potential tuberculosis (TB), it is essential to approach the situation with a comprehensive understanding of the diagnostic process and the implications of the findings. Based on your description, you underwent a chest X-ray that revealed a small shadow in the lungs, which raised suspicion for tuberculosis. Subsequently, you had a CT scan and sputum tests, all of which returned negative results for TB. However, your doctor still recommended a six-month course of medication based on the CT findings.

Firstly, it is important to understand that while imaging studies like X-rays and CT scans can provide valuable information about lung abnormalities, they are not definitive for diagnosing tuberculosis. The presence of a shadow or abnormality on a CT scan can be indicative of various conditions, including infections, malignancies, or benign lesions. In the case of TB, the typical findings on imaging include cavitary lesions, nodules, or consolidations, but these can also be seen in other diseases.

The fact that your sputum tests returned negative for TB is significant. Sputum smear and culture tests are the gold standard for diagnosing pulmonary tuberculosis. A negative result, especially from three separate tests, suggests that active TB is unlikely. However, it is also important to consider that TB can sometimes be present in a latent form, where the bacteria are inactive and not causing symptoms, but can still be detected through other means, such as a tuberculin skin test or interferon-gamma release assays (IGRAs).

Given your concerns about the diagnosis and the potential side effects of a six-month medication regimen, it is entirely reasonable to seek a second opinion. Consulting another healthcare provider or a specialist in infectious diseases or pulmonology can provide you with additional insights and possibly alternative diagnostic approaches. They may recommend further testing, such as a bronchoscopy or additional imaging studies, to clarify the nature of the lung abnormality.

It is also crucial to communicate openly with your current physician about your concerns. They should be willing to discuss the rationale behind their diagnosis and treatment plan, as well as the risks and benefits of the proposed medication. If there is uncertainty regarding the diagnosis, your physician may agree that further evaluation is warranted.

In summary, while the CT findings and the initial suspicion of tuberculosis are concerning, the negative sputum tests significantly reduce the likelihood of active TB. It is advisable to seek a second opinion to ensure that you are receiving the most accurate diagnosis and appropriate treatment. Remember, your health and peace of mind are paramount, and pursuing clarity in your medical care is both your right and responsibility.

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