Managing Spinal Compression Fractures in Elderly Lung Cancer Patients - Orthopedics

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Lung adenocarcinoma metastasizing to the spine?


An 85-year-old male with lung adenocarcinoma has metastasized to the spine, resulting in a compression fracture of the 12th vertebra.
He is currently experiencing right hip joint pain and is unable to sit for long periods due to severe pain, leading to bed rest.
Dr.
Chen, in this situation, is it appropriate to perform surgery for the compression fracture at the 12th vertebra? Thank you!

Xiao Mei, 50~59 year old female. Ask Date: 2020/06/22

Dr. Chen Bochen reply Orthopedics


Hello, regarding the treatment options for cancer-related bone metastasis, please consider the following:
1.
Chemotherapy or targeted therapy that should be continued as per your attending physician's instructions.

2.
If there is only a compressive fracture without nerve involvement, vertebroplasty (commonly known as spinal cementing) can be performed to achieve pain relief, which can be done under local anesthesia or intravenous sedation without the need for intubation, thus posing relatively low risk.

3.
If there is mild nerve compression, corticosteroids can be used to slightly reduce swelling of the nerves and tumor, alleviating nerve pressure.

4.
In cases of severe nerve compression, decompression surgery with instrumentation is required, which generally necessitates intubation and carries higher risks; however, if unavoidable, it is advisable to weigh the risks and benefits before making a decision.

5.
Regardless of the treatment chosen, it is recommended to include localized radiation therapy.
I hope this addresses your concerns.
Wishing you well and peace of mind.

Dr.
Chen Po-Chen, Orthopedic Department, Changhua Hospital

Reply Date: 2020/06/22

More Info


Managing spinal compression fractures in elderly patients, particularly those with a history of lung cancer, requires a careful and individualized approach. In the case of an 85-year-old male patient with lung adenocarcinoma that has metastasized to the spine, resulting in a compression fracture of the 12th vertebra and associated pain, several factors must be considered before deciding on surgical intervention.


Understanding the Condition
Spinal compression fractures in elderly patients can occur due to various reasons, including osteoporosis, trauma, or malignancy. In this patient’s case, the fracture is likely due to the metastatic disease affecting the structural integrity of the vertebra. The presence of pain, particularly in the right hip and the inability to sit for prolonged periods, indicates that the fracture may be causing significant discomfort and potentially impacting the quality of life.


Treatment Options
1. Conservative Management: For patients with stable compression fractures that do not involve neurological compromise, conservative management is often the first line of treatment. This may include:
- Pain Management: Medications such as NSAIDs, acetaminophen, or opioids may be prescribed to manage pain effectively.

- Physical Therapy: Gentle exercises and physical therapy can help improve mobility and strengthen surrounding muscles, which may alleviate some pain.

- Bracing: A back brace may provide support and reduce pain during activities.

2. Minimally Invasive Procedures: If conservative management fails to provide relief, or if the fracture is causing significant pain or functional impairment, minimally invasive procedures may be considered:
- Vertebroplasty or Kyphoplasty: These procedures involve the injection of cement into the fractured vertebra to stabilize it and reduce pain. They are typically performed under local anesthesia and have a lower risk profile compared to open surgery.

3. Surgical Intervention: If there is evidence of neurological compromise (e.g., significant nerve compression) or if the fracture is unstable, surgical intervention may be warranted. This could involve:
- Decompression Surgery: If the fracture is causing nerve compression, a decompression procedure may be necessary to relieve pressure on the spinal cord or nerves.

- Spinal Fusion: In cases where there is instability, a spinal fusion may be performed to stabilize the spine.


Considerations for Surgery
Given the patient’s age and overall health status, the risks and benefits of surgery must be carefully weighed. Surgical risks in elderly patients can include:
- Anesthesia complications
- Infection
- Prolonged recovery time
- Potential for increased pain or complications post-surgery

Multidisciplinary Approach
It is crucial to involve a multidisciplinary team in the management of this patient. This team may include:
- Oncologists: To manage the underlying lung cancer and any systemic therapies that may be indicated.

- Pain Management Specialists: To optimize pain control strategies.

- Physical Therapists: To assist with rehabilitation and mobility.

- Surgeons: To evaluate the need for surgical intervention based on imaging studies and clinical findings.


Conclusion
In conclusion, the management of spinal compression fractures in elderly patients with lung cancer requires a comprehensive assessment of the individual’s condition, including pain levels, functional status, and overall health. While surgical intervention may be appropriate in certain cases, it is essential to consider the potential risks and benefits, particularly in an 85-year-old patient. A conservative approach may be suitable initially, with the option to pursue more invasive treatments if necessary. Engaging a multidisciplinary team will ensure that the patient receives holistic care tailored to their specific needs and circumstances.

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