Bladder Biopsy Results and Urinary Health Concerns - Urology

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Bladder biopsy


On December 1, 2012, the bladder biopsy report indicated a diagnosis of urinary bladder (neck), transurethral biopsy, cystitis glandularis.
The specimen submitted consisted of two pieces of mucosal tissue measuring up to 0.3 cm in greatest dimension, all for sectioning.

NOTE: Xone.

On January 30, 2013, the uroflowmetry results were as follows:
- Peak flow rate: 6 ml/s
- Time to peak flow: 110 s
- Voided volume: 186 ml
- Flow time: 112 s
- Voiding time: 222 s
- Average flow rate: 2 ml/s
- Residual urine: 40 ml
Since elementary school, I have had difficulty urinating in public restrooms when others are nearby, leading me to hold my urine for extended periods.
I would wait until the restroom was empty before I felt comfortable urinating, resulting in severe urinary retention.
I only realized by the age of 28 that this chronic retention could severely impact my life.
Now, I am able to use public restrooms.

Symptoms: In the morning, I experience difficulty urinating due to holding it for too long during sleep, often needing to urinate multiple times before feeling completely empty.
I sometimes experience urgency, and prolonged urgency can lead to difficulty in urination, requiring a break before I can fully empty my bladder.
I have a significant issue with frequent urination.
Seven years ago, I discovered microscopic hematuria during a urinalysis, which led to a cystoscopy; however, I have only experienced hematuria once.
Since then, I have not had any occurrences of microscopic hematuria.
I have only undergone cystoscopy once.

1.
Currently, I visit the hospital every three months for urine tests to check for microscopic hematuria, and I have no blood in my urine at this time.
Is this level of monitoring sufficient? Are there any additional tests that would provide more assurance? The cystoscopy report was conducted on December 1, 2012.

AC, 30~39 year old female. Ask Date: 2020/06/24

Dr. Li Minghui reply Urology


Hello: Since your hematuria occurred in 2012 and you have been regularly monitored without any recurrence of hematuria, it should be fine now.
You can continue with regular follow-ups.
Attached are the common causes of hematuria for your reference.

Reply Date: 2020/06/24

More Info


Understanding bladder biopsy results and urinary health concerns is crucial for maintaining overall well-being, especially given your history of urinary issues and the results from your bladder biopsy and uroflowmetry tests.

Interpretation of Your Bladder Biopsy Results
Your bladder biopsy report indicates a diagnosis of "cystitis glandularis," which is a condition characterized by the presence of glandular tissue in the bladder lining. This condition is generally considered benign, but it can sometimes be associated with chronic irritation or inflammation of the bladder. The biopsy results showed that the specimen consisted of two pieces of mucosal tissue measuring up to 0.3 cm, which is relatively small and typically not indicative of malignancy. However, it is essential to monitor this condition periodically, as there is a slight risk that it could develop into something more serious over time.


Current Symptoms and Concerns
You mentioned experiencing difficulty urinating in the morning, urgency, and a feeling of incomplete bladder emptying. These symptoms can be linked to several factors, including your history of holding urine for extended periods, which can lead to bladder dysfunction. Chronic retention of urine can stretch the bladder and potentially lead to changes in bladder wall structure and function, contributing to symptoms like urgency and difficulty initiating urination.


Recommended Follow-Up and Monitoring
Given your history and current symptoms, your practice of having urine tests every three months is a good start, especially since you have not experienced any further episodes of hematuria (blood in urine). However, considering your symptoms and the previous diagnosis, it may be prudent to include additional evaluations:
1. Urodynamic Studies: These tests can provide more detailed information about how well your bladder and urethra are functioning. They can help assess bladder capacity, pressure, and the flow of urine.

2. Bladder Ultrasound: This non-invasive test can help evaluate the bladder's structure and check for any abnormalities, including residual urine volume after voiding.

3. Regular Cystoscopy: Since you have a history of cystitis glandularis, it may be advisable to have a cystoscopy every 1-2 years to monitor for any changes in the bladder lining, especially if you experience any new symptoms.

4. Lifestyle Modifications: It’s essential to adopt habits that promote urinary health. Avoiding prolonged periods of holding urine, maintaining adequate hydration, and practicing good hygiene can help reduce the risk of urinary tract infections and other complications.


Conclusion
In summary, while your current monitoring every three months is a good practice, considering your symptoms and history, it may be beneficial to incorporate additional tests such as urodynamic studies and bladder ultrasounds into your follow-up care. Regular communication with your healthcare provider is essential to ensure that any changes in your urinary health are promptly addressed. If you experience any new or worsening symptoms, do not hesitate to seek medical attention. Your proactive approach to understanding and managing your urinary health is commendable and will contribute significantly to your overall well-being.

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