Causes and Concerns of Testicular Enlargement: A Guide for Patients - Urology

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Testicular enlargement


I have diabetes, but my blood sugar levels are not high.
In June, I noticed that my right testicle was enlarged, with an abnormal shape, and it feels hard to the touch, but it is not painful, and I have no other symptoms.
Blood tests showed normal cancer markers, and a CT scan report indicated no other cancer cells.
Could there be other factors causing the testicular enlargement? Additionally, is it possible to perform a biopsy?

Mr. Zhan, 40~49 year old female. Ask Date: 2020/07/05

Dr. Sun Hongshun reply Urology


Hello Mr.
Jan: Testicular enlargement can be caused by inflammation or other reasons aside from cancer.
An abnormal cancer marker does not necessarily indicate malignancy, and vice versa.
How long have you been experiencing these symptoms? What comprehensive examinations have you undergone? If necessary, please visit the hospital, and we will arrange for a detailed examination for you.
A testicular biopsy can be performed, but caution is advised, as improper handling could lead to the risk of metastasis if it is malignant.

Reply Date: 2020/07/05

More Info


Testicular enlargement can be a concerning symptom for many patients, and it is essential to understand the potential causes and implications. In your case, you have noted that you have diabetes, but your blood sugar levels are well-controlled. You also mentioned that you have experienced enlargement of the right testicle, which feels hard to the touch but is not painful, and that you have undergone blood tests and a CT scan that did not indicate the presence of cancer cells.
There are several potential causes for testicular enlargement, and it is crucial to consider each one carefully. Here are some common causes:
1. Epididymal Cyst or Spermatocele: These are fluid-filled sacs that can develop in the epididymis, the tube that stores sperm. They are usually benign and may not cause any symptoms other than swelling.

2. Hydrocele: This condition involves the accumulation of fluid around the testicle, leading to swelling. Hydroceles can occur due to injury, infection, or inflammation.

3. Varicocele: This refers to the enlargement of veins within the scrotum, similar to varicose veins. Varicoceles can cause discomfort and may affect fertility but are generally not dangerous.

4. Infection or Inflammation: Conditions such as epididymitis (inflammation of the epididymis) or orchitis (inflammation of the testicle) can cause swelling and discomfort. These infections can be bacterial or viral.

5. Testicular Tumors: While you mentioned that your blood tests did not indicate cancer, it is still important to consider the possibility of benign or malignant tumors. Testicular cancer can present as a painless lump or swelling, and it is crucial to rule this out through appropriate imaging and possibly a biopsy.

6. Trauma or Injury: Any trauma to the testicle can lead to swelling and changes in shape. This may not always be accompanied by pain.

Given your situation, where the testicle is enlarged but not painful and there are no signs of cancer from your imaging studies, it is still advisable to follow up with a urologist. They may recommend further evaluation, including a testicular ultrasound, which is a non-invasive imaging technique that can provide more detailed information about the structure of the testicle and surrounding tissues.

Regarding your question about a biopsy, it is generally not the first step in evaluating testicular enlargement unless there is a strong suspicion of malignancy or if the imaging studies suggest an abnormality that warrants further investigation. A biopsy can be invasive and carries risks, so it is typically reserved for cases where other diagnostic methods have not provided clear answers.

In conclusion, while there are several potential causes for testicular enlargement, many of them are benign. It is essential to have a thorough evaluation by a healthcare professional, particularly a urologist, who can guide you through the appropriate diagnostic steps and determine whether any treatment is necessary. Regular follow-ups and monitoring are crucial, especially given your diabetes, as underlying conditions can sometimes complicate symptoms. Always communicate openly with your healthcare provider about any changes you notice and any concerns you have regarding your health.

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