Thyroid Dysfunction: Impact on Fertility and TSH Levels - Internal Medicine

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Hypothyroidism issues?


Six months ago, I had a premarital health check-up and my TSH level was 1.57 uIU/mL, which is normal.
Recently, while preparing for pregnancy and taking traditional Chinese medicine, I had another test (on the second day of my menstrual cycle) and my TSH level was surprisingly high at 9.29 uIU/mL.
I would like to ask: 1.
Is it possible for TSH levels to fluctuate this much within six months? 2.
Can such a level lead to infertility? 3.
What is the ideal TSH level for conception? 4.
Could the traditional Chinese medicine I took for pregnancy preparation (including Liuwei Dihuang Wan, Sijunzi Decoction, Danshen, Zhi Gancao Decoction, and Yimucao) have caused an increase in TSH levels (hypothyroidism)?

nana, 20~29 year old female. Ask Date: 2020/07/05

Dr. Xie Rongyuan reply Internal Medicine


Hello: Regarding your question, here is the explanation: If TSH levels are abnormal (elevated), you should consult an endocrinologist to check Free T4.
Both hyperthyroidism and hypothyroidism can affect the secretion of FSH, LH, and HCG, potentially leading to infertility.
For herbal medicine, please consult a traditional Chinese medicine practitioner.
Thank you for your inquiry!

Reply Date: 2020/07/05

More Info


Thyroid dysfunction can significantly impact fertility, and understanding the relationship between thyroid-stimulating hormone (TSH) levels and reproductive health is crucial for those trying to conceive. Let's address your questions one by one.

1. Can TSH levels fluctuate significantly within six months?
Yes, TSH levels can fluctuate due to various factors, including stress, changes in diet, medications, and underlying health conditions. A TSH level of 1.57 uIU/mL is considered normal, while a level of 9.29 uIU/mL indicates hypothyroidism. Such a significant change in TSH levels over a six-month period is possible, especially if there are changes in your health status or lifestyle. It is essential to monitor thyroid function regularly, especially when planning for pregnancy.

2. Can elevated TSH levels lead to infertility?
Yes, elevated TSH levels can lead to infertility. Hypothyroidism can disrupt the normal functioning of the hypothalamic-pituitary-gonadal axis, which regulates reproductive hormones such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This disruption can lead to irregular menstrual cycles, anovulation (failure to ovulate), and other reproductive issues, making it more challenging to conceive. Therefore, it is crucial to manage thyroid levels effectively when trying to become pregnant.

3. What is the ideal TSH level for conception?
For women trying to conceive, the American Thyroid Association recommends that TSH levels be maintained below 2.5 uIU/mL. This target is particularly important for women undergoing fertility treatments or those with a history of thyroid dysfunction. If your TSH levels are elevated, it is advisable to consult with an endocrinologist to discuss treatment options, which may include thyroid hormone replacement therapy.

4. Could traditional Chinese medicine (TCM) have caused an increase in TSH levels?
While traditional Chinese medicine, including herbal remedies like Liu Wei Di Huang Wan and Si Jun Zi Tang, is often used to support overall health and fertility, it is essential to consider that some herbal ingredients may interact with thyroid function. However, there is limited scientific evidence directly linking these specific herbal remedies to increased TSH levels. It is crucial to discuss any herbal treatments with a healthcare provider, especially when managing thyroid conditions. If you suspect that the herbal remedies may be affecting your thyroid function, it would be wise to discontinue their use and consult a healthcare professional for further evaluation.

In summary, thyroid health is vital for fertility, and significant fluctuations in TSH levels can impact your ability to conceive. Regular monitoring and management of thyroid function are essential, particularly when planning for pregnancy. If you have concerns about your TSH levels or the impact of any treatments you are using, it is crucial to consult with a healthcare provider who specializes in reproductive endocrinology or thyroid disorders. They can provide personalized recommendations and treatment options to help you achieve a healthy pregnancy.

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