Syphilis: Concerns About Positive RPR Test Results - Urology

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Syphilis concerns?


Last week, I went for a health check-up, and the results indicated that my RPR was positive at 1:1X, prompting me to undergo further testing for TPPA.
I find this very strange because I haven't had sexual intercourse for over two years, and two years ago, I only had sexual relations with my spouse.
It's puzzling how I could test positive for syphilis (I also had a health check-up two years ago, and it didn't show any positive results; why is it suddenly positive this year?).
This has made me extremely worried, to the point that I can't sleep! Could it be that I got infected during my recent visits to a traditional Chinese medicine practitioner for acupuncture and bloodletting due to my lower back pain? Can syphilis be transmitted without sexual contact? This is really frightening! How can I feel safe going to a traditional Chinese medicine practitioner in the future? Does an RPR value of 1:1X mean that I have syphilis, or is it a false positive as mentioned online? What is a false positive? What circumstances can lead to a false positive result? Please respond as soon as possible! Thank you very much for taking the time to reply!

C, 50~59 year old female. Ask Date: 2020/07/20

Dr. Du Shixi reply Urology


Hello: Further testing for TPHA may be necessary, as there is currently no confirmed diagnosis.
Please bring the report to the urology department for evaluation.
False positives can occur, where a negative result is mistakenly reported as positive, and this situation is quite common.
Your case requires assessment by a physician.
Wishing you good health.
You can refer to CDC information at https://www.cdc.gov.tw/Category/QAPage/mPTPX2RgyJVa3o7Xph_4HQ.

Reply Date: 2020/07/20

More Info


Understanding your concerns about a positive RPR (Rapid Plasma Reagin) test result is crucial, especially given your history and the context of your recent health check. Let's break down the implications of your test results and address your worries.


What Does a Positive RPR Test Mean?
A positive RPR test indicates the presence of non-treponemal antibodies in your blood, which are typically associated with syphilis. However, it is essential to understand that the RPR test is not specific to syphilis. This means that while a positive result suggests the possibility of syphilis, it does not confirm the diagnosis. Further testing is necessary, usually with a treponemal test like the TPPA (Treponema pallidum particle agglutination assay), which can confirm the presence of the syphilis-causing bacteria.


The Concept of False Positives
A "false positive" occurs when a test indicates a condition is present when it is not. In the case of the RPR test, several factors can lead to false positive results, including:
1. Recent Infections: Other infections, such as viral infections (like HIV or hepatitis), can sometimes trigger a positive RPR.

2. Autoimmune Disorders: Conditions like lupus or rheumatoid arthritis can cause the body to produce antibodies that react in the RPR test.

3. Pregnancy: Pregnant women may also show positive RPR results due to physiological changes.

4. Certain Medications: Some medications can interfere with test results.

5. Technical Errors: Laboratory errors can also lead to incorrect results.


Your Specific Situation
Given that you have not engaged in sexual activity for over two years and had negative results in previous tests, it is understandable to feel anxious about this sudden change. It is important to note that syphilis is primarily transmitted through sexual contact, but it can also be transmitted through non-sexual means, such as from mother to child during pregnancy or through blood transfusions (though this is rare in modern medical practices).

Your recent treatments, such as acupuncture or other forms of therapy, are unlikely to be a source of syphilis infection. Syphilis is not transmitted through casual contact or therapeutic procedures like acupuncture.


Next Steps
1. Follow-Up Testing: It is crucial to follow through with the recommended TPPA test. This test will help clarify whether you have a current syphilis infection or if your RPR result was a false positive.


2. Consult a Healthcare Provider: Discuss your concerns with a healthcare provider who can provide personalized advice based on your medical history and the specifics of your test results.

3. Monitor Symptoms: If you experience any symptoms such as sores, rashes, or unusual changes in your health, report these to your healthcare provider immediately.


Conclusion
While a positive RPR test can be alarming, it does not automatically mean you have syphilis. The possibility of a false positive is significant, and further testing is essential to determine your actual health status. Remember, many factors can influence test results, and it is best to consult with a healthcare professional for accurate diagnosis and peace of mind. Your health and well-being are paramount, and taking proactive steps will help you navigate this situation effectively.

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