Medication Issues in Gastroenterology: Takepronod and Herbal Interactions - Gastroenterology and Hepatology

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Medication-related issues


Hello Doctor,
1.
I have been taking medication for gastroesophageal reflux disease, and my doctor prescribed Takepronod (a dissolvable tablet).
Normally, dissolvable tablets should be held in the mouth until they dissolve, but I accidentally swallowed it with water because I was taking three other stomach medications at the same time and forgot it was a dissolvable tablet.
I felt like it got stuck in my throat while dissolving, and even after drinking water, it still feels uncomfortable.
I would like to ask if Takepronod, which is used to treat esophageal ulcers, could cause ulcers or inflammation if it indeed got stuck in my throat or esophagus.
I thought that since it is a dissolvable tablet, it should dissolve completely with enough water, but I still feel uneasy about it, so I wanted to consult you.
2.
Additionally, if I am taking traditional Chinese medicine alongside this, could there be an additive effect? For example, if both the Chinese and Western medications suppress gastric acid secretion, could this lead to insufficient gastric acid and cause digestive issues, even if I space them out by 1-2 hours? Thank you, Doctor.

Awei, 20~29 year old female. Ask Date: 2020/08/25

Dr. Chen Shidian reply Gastroenterology and Hepatology


This medication is considered safe for oral administration, and there is currently no research proving any interactions with traditional Chinese medicine.

Reply Date: 2020/08/25

More Info


When it comes to understanding medication issues in gastroenterology, particularly with the use of Takepronod (a proton pump inhibitor) and herbal remedies, there are several important considerations to keep in mind.

Firstly, regarding your concern about accidentally swallowing Takepronod without allowing it to dissolve in your mouth, it’s important to note that while the medication is designed to dissolve sublingually (under the tongue), swallowing it whole should not cause significant harm. Proton pump inhibitors like Takepronod work by reducing stomach acid production, and they are generally well-tolerated. However, if the medication were to adhere to the throat or esophagus, it could potentially cause irritation or discomfort. This is particularly true if the medication does not dissolve properly and remains in contact with the mucosal lining for an extended period. Drinking water to help wash it down is a good practice, and if you continue to feel discomfort, it would be advisable to consult your healthcare provider for further evaluation.

Now, regarding your second question about the interaction between Western medications like Takepronod and herbal remedies, this is a critical area of concern. Herbal supplements can indeed have pharmacological effects that may interact with conventional medications. For instance, many herbal products can either enhance or inhibit the effects of medications that suppress gastric acid secretion.
If both the herbal remedy and Takepronod are working to reduce stomach acid, there is a potential risk of excessive acid suppression. This could lead to digestive issues, such as malabsorption of nutrients, since stomach acid plays a crucial role in breaking down food and activating digestive enzymes. Additionally, prolonged suppression of gastric acid can lead to an overgrowth of bacteria in the stomach and intestines, which can cause further gastrointestinal discomfort and complications.

It is essential to maintain a gap of at least 1-2 hours between taking herbal supplements and medications like Takepronod to minimize the risk of interaction. However, the specific herbs you are considering can significantly influence the nature of the interaction. For example, herbs like ginger or peppermint may aid digestion, while others like licorice can potentially exacerbate acid reflux symptoms.

In conclusion, while it is generally safe to use Takepronod and herbal remedies concurrently, it is crucial to be aware of their potential interactions and effects on your digestive health. Always consult with your healthcare provider before starting any new herbal supplements, especially if you are already on prescribed medications. They can provide personalized advice based on your health history and current medications, ensuring that you receive the most effective and safe treatment for your gastroenterological issues.

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