Ovarian Tumors: When to Consider Surgery vs. Observation - Obstetrics and Gynecology

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Ovarian tumor


I would like to ask about my family member who underwent a total abdominal hysterectomy and bilateral oophorectomy due to low-grade ovarian cancer two years ago.
After regular follow-ups, a tumor was discovered in the left abdomen last year.
Blood tests for CA-125 were normal, and a PET scan showed no significant abnormalities.
The physician suggested continued observation, but ultimately, surgery was decided to remove the tumor.
In March of this year, another tumor was found in the same area of the left abdomen, growing approximately one centimeter each month.
Blood tests for CA-125 remained stable, and ultrasound indicated no vascular structures around the tumor, with CT reports showing no signs of metastasis.
The doctor stated that surgery is the only option, as there are no suitable medications or treatments available.
I would like to know if the physician recommends proceeding with surgery soon or if it would be better to observe for a while longer before surgery.
Are there any other treatment options available? Additionally, I would like to understand if this situation is likely to recur in the future.
Thank you for your response.

Niming, 20~29 year old female. Ask Date: 2020/09/12

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, if there is continuous growth, surgery should be considered.
If the surgery can achieve clean margins, there should be no recurrence, unless it cannot be completely removed.
Wishing you good health.

Reply Date: 2020/09/12

More Info


When it comes to understanding ovarian tumors, particularly in the context of when to consider surgery versus observation, there are several factors to take into account. Your family history of low-grade ovarian cancer adds an important layer to your situation, as it may influence both your risk assessment and the management approach.

Firstly, the presence of a tumor, especially in someone with a history of ovarian cancer, warrants careful evaluation. The fact that your CA-125 levels have remained normal is a positive sign, as elevated levels can indicate malignancy. However, normal CA-125 levels do not completely rule out the possibility of cancer, especially in the context of a growing tumor. The size and growth rate of the tumor are critical factors; a tumor that is increasing in size by about one centimeter each month is concerning and suggests that it may require intervention.

In general, the decision to proceed with surgery versus observation depends on several criteria:
1. Tumor Characteristics: The size, shape, and appearance of the tumor on imaging studies (like ultrasound or CT scans) can provide clues about its nature. Tumors that are solid, irregular, or have septations (internal divisions) are more likely to be malignant. In your case, the absence of vascular structures around the tumor is reassuring, but the consistent growth is a red flag.

2. Patient Symptoms: If you are experiencing symptoms such as pain, bloating, or changes in bowel or urinary habits, these may indicate that the tumor is affecting surrounding structures and may necessitate surgical intervention.

3. Risk Factors: Given your family history of ovarian cancer, you may have an increased risk for developing malignant tumors. This history should be factored into the decision-making process.

4. Monitoring and Follow-Up: Regular follow-up with imaging and blood tests is essential. If the tumor continues to grow or if there are any changes in your clinical status, surgery may become necessary.

In your specific case, since the tumor has shown consistent growth and there are no other effective treatment options available, it may be prudent to consider surgery sooner rather than later. Waiting for further observation could lead to complications or a more advanced stage of disease if the tumor turns out to be malignant.
Regarding the possibility of recurrence, it is not uncommon for ovarian tumors to recur, especially in individuals with a history of ovarian cancer. Regular monitoring and follow-up are crucial in managing your health post-surgery.
In conclusion, while observation can be appropriate in certain situations, your case seems to lean towards the necessity of surgical intervention due to the tumor's growth pattern and your medical history. It is essential to have a thorough discussion with your healthcare provider about the risks and benefits of surgery versus continued observation, as well as any other potential treatment options that may be available. Always ensure that you feel comfortable with the plan moving forward and that all your questions are addressed.

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