How Long for Strong Antibiotics to Work on Lung Infections?

Q: How Long for Strong Antibiotics to Work on Lung Infections?

Dear Lin： Postoperative lung adenocarcinoma complicated by pulmonary infection and pleural effusion is indeed challenging to manage. <br>Generally, we assess the effectiveness of medications, taking into account not only the types of drugs selected but also the patient's immune c

The effectiveness of the strongest antibiotics for treating severe pneumonia caused by abdominal bacterial infections can vary depending on several factors, including the specific bacteria involved, the patient's overall health, and the presence of any underlying conditions. Generally, improvement may be observed within 48 to 72 hours after starting appropriate antibiotic therapy. However, it is crucial to monitor the patient's response and adjust treatment as necessary based on clinical evaluation and laboratory results?

My father underwent surgery for right upper lung adenocarcinoma, and subsequently developed pneumonia in the left lung, which was found to be caused by Enterobacter hormaechei.
The doctor has prescribed the strongest antibiotic available, and treatment has been ongoing for three days, but the pneumonia remains severe.
I would like to know how many days it typically takes for the strongest antibiotics to show effectiveness.
My father also has pleural effusion, is receiving oxygen support at 70%, and has some pulmonary fibrosis.
We are quite anxious and hope to receive a professional response from a doctor.

Lin, 20~29 year old female. Ask Date: 2020/09/19

Dr. Huang Yiwen reply Pulmonology

Dear Lin: Postoperative lung adenocarcinoma complicated by pulmonary infection and pleural effusion is indeed challenging to manage.
Generally, we assess the effectiveness of medications, taking into account not only the types of drugs selected but also the patient's immune capacity.
Three days is merely the minimum observation period; we also need to rely on other vital signs and clinical data for a comprehensive evaluation.
It may require more patience and allowing the physician some space to improve the situation.
Thank you for your inquiry, and Changhua Hospital is concerned about you.

Reply Date: 2020/09/19

More Info

When it comes to treating lung infections caused by bacteria such as Enterobacter hormaechei, the effectiveness of strong antibiotics can vary significantly based on several factors, including the specific antibiotic used, the severity of the infection, the patient's overall health, and any underlying conditions. In your father's case, having undergone surgery for lung adenocarcinoma and now facing a pneumonia infection, the situation is indeed complex and requires careful management.

Typically, antibiotics may take anywhere from 48 to 72 hours to show noticeable improvement in symptoms, but this can vary widely. In some cases, especially with severe infections or in patients with compromised immune systems, it may take longer for the antibiotics to take effect. The initial three days of treatment that your father has undergone is often just the beginning of the observation period. It is essential to monitor not only the symptoms but also other vital signs and laboratory results to assess the effectiveness of the treatment.

In cases of pneumonia caused by resistant bacteria like Enterobacter hormaechei, the choice of antibiotic is crucial. The "strongest" antibiotic may not always be the most effective if the bacteria are resistant to it. Therefore, it is important for the healthcare team to review culture and sensitivity results to ensure that the antibiotic being administered is appropriate for the specific strain of bacteria causing the infection. If there is no improvement after a few days, the medical team may consider switching to a different antibiotic based on these results.

Additionally, your father's condition is complicated by the presence of pleural effusion (fluid in the lungs), which can further hinder recovery. In some cases, draining the fluid may be necessary to improve breathing and allow the antibiotics to work more effectively. The presence of lung fibrosis may also impact the healing process, as it can reduce lung function and complicate the infection.

Given your father's current oxygen saturation levels and the severity of his pneumonia, it is crucial to maintain close communication with his healthcare providers. They may need to adjust the treatment plan based on his response to the antibiotics and any changes in his clinical status. It is also important to be patient, as recovery from severe lung infections can take time, especially in patients with underlying health issues.

In summary, while antibiotics generally start to show effects within a few days, the timeline can vary based on individual circumstances. Continuous monitoring and possibly adjusting the treatment plan will be essential in managing your father's pneumonia effectively. If there are concerns about his progress, do not hesitate to discuss them with his healthcare team, as they can provide the most accurate guidance tailored to his specific situation.

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