Interactions Between Emergency Contraceptives and Other Medications - Obstetrics and Gynecology

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Interactions of Emergency Contraceptive Pills with Medications


Hello, Doctor: I have been taking oral contraceptives for over a year.
I started taking Noxafil (posaconazole) 1000 mg for 7 days from September 1 to September 8, during which I continued to take my oral contraceptives as usual.
The instructions mentioned that this medication may interact with oral contraceptives.
How long should I wait before engaging in unprotected intercourse? Additionally, on September 10, I had brief unprotected intercourse but did not ejaculate.
Is there a possibility of pregnancy?

Ms. Zheng, 20~29 year old female. Ask Date: 2020/09/21

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, generally there is not much impact.
If you take the medication on time, it will be effective for contraception.
Wishing you good health.

Reply Date: 2020/09/21

More Info


When considering the interactions between emergency contraceptives and other medications, it is essential to understand how these medications work and their potential effects on each other. In your case, you have been taking a combined oral contraceptive (the "事前避孕藥") for over a year and have recently taken a medication called "諾快寧膜衣錠" (likely referring to a form of antibiotic or antifungal medication).
1. Interactions Between Medications: Certain medications can affect the efficacy of hormonal contraceptives. For example, some antibiotics, particularly rifampicin and rifabutin, are known to reduce the effectiveness of birth control pills. However, most commonly prescribed antibiotics, including those that are not in the rifampicin class, do not significantly affect the efficacy of hormonal contraceptives. If "諾快寧膜衣錠" is an antibiotic, it is crucial to check if it belongs to the rifampicin class or has similar properties. If it does not, the risk of reduced contraceptive efficacy is low.

2. Timing for Unprotected Intercourse: If you have been taking your oral contraceptive consistently and correctly, and if the medication you took does not significantly interact with your contraceptive, you should be protected from pregnancy. However, if there is any concern about interaction, it is generally recommended to use additional contraception (such as condoms) for at least 7 days after completing the course of the interacting medication. Since you completed the medication on 9/8, you would typically be safe to have unprotected intercourse starting from 9/15, assuming no other factors are at play.

3. Risk of Pregnancy: Regarding your concern about the unprotected intercourse on 9/10, if you were taking your contraceptive correctly and the medication you took does not interfere with its effectiveness, the risk of pregnancy is minimal. The fact that there was no ejaculation further reduces the likelihood of conception. However, it is important to remember that no contraceptive method is 100% effective, and there is always a small risk of pregnancy with any unprotected intercourse.

4. Emergency Contraceptive Consideration: If you are still concerned about the possibility of pregnancy after the unprotected intercourse, you may consider taking an emergency contraceptive pill (ECP) as a precaution. ECPs are most effective when taken as soon as possible after unprotected intercourse, ideally within 72 hours, but some types can be effective up to 5 days after.

5. Consultation with Healthcare Provider: It is always advisable to consult with your healthcare provider or pharmacist regarding any potential interactions between medications you are taking. They can provide personalized advice based on your specific situation and the medications involved.

In summary, if your contraceptive has been taken correctly and the medication you took does not significantly interact with it, you should be protected. However, if you have any doubts or experience any unusual symptoms, it is best to consult a healthcare professional for further guidance.

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