HCG Levels in PCOS: What Do They Mean for Pregnancy? - Obstetrics and Gynecology

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Polycystic ovary syndrome (PCOS) hCG levels?


Hello Dr.
Tsao: I have three questions I would like to ask you.
I underwent artificial insemination with sperm implantation on September 10, and on September 25, I returned for a blood test and urine test (I had a faint second line on a home pregnancy test on September 24).
The results showed no second line on the urine test, but the blood test indicated a level of 14.5.
The doctor told me that a normal level should be 5, and that my elevated level of 14.5 suggests that I may have been pregnant but experienced a miscarriage.
Is this true? I was advised to return for another blood test on October 2 to check if the levels have increased.
If they decrease, it indicates a miscarriage; if they increase, it could indicate an ectopic pregnancy.
However, I mentioned to the doctor that I feel movement on both sides but no pain, and the doctor said that would rule out an ectopic pregnancy.
But if the levels increase, it could be concerning.
What does this mean? I understand that polycystic ovary syndrome (PCOS) can lead to irregular ovulation and that implantation of the fertilized egg in the uterus can sometimes be delayed.
Is it possible that I could experience such a situation? Thank you for your response.

Jia Er, 30~39 year old female. Ask Date: 2020/09/26

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, if the blood test values are elevated, it indicates pregnancy; if they decrease, it may suggest a miscarriage.
Ectopic pregnancy should be monitored.
Wishing you good health.

Reply Date: 2020/09/26

More Info


Understanding HCG Levels in PCOS: What Do They Mean for Pregnancy?
When it comes to understanding HCG (human chorionic gonadotropin) levels, especially in the context of polycystic ovary syndrome (PCOS), it is crucial to grasp the implications of these hormone levels on pregnancy outcomes. HCG is a hormone produced during pregnancy, and its levels are often used to confirm pregnancy and monitor its progression.

In your case, you mentioned that after undergoing artificial insemination on September 10, you had a blood test on September 25 that showed an HCG level of 14.5 mUI/ml. While your doctor indicated that a normal HCG level should be at least 5 mUI/ml to confirm pregnancy, your level being at 14.5 suggests that there is some level of HCG present, which could indicate a pregnancy. However, it is also possible that this level could be due to a previous pregnancy that ended in miscarriage, especially since you mentioned that the urine test did not show a positive result.

The follow-up blood test scheduled for October 2 is critical. If your HCG levels rise significantly, it would typically indicate a viable pregnancy. Conversely, if the levels decrease, it may suggest a miscarriage. The concern about ectopic pregnancy arises when HCG levels rise but do not correspond with expected increases, particularly if accompanied by symptoms such as abdominal pain. Since you reported no pain, your doctor may have assessed that the likelihood of an ectopic pregnancy is lower, but monitoring is still essential.

PCOS can complicate pregnancy due to irregular ovulation and potential delays in implantation. Women with PCOS may experience fluctuations in hormone levels, which can affect the timing of ovulation and the ability of the fertilized egg to implant in the uterus. This can lead to situations where HCG levels may not rise as expected, or where implantation may be delayed, resulting in lower HCG levels initially.

In your situation, it is essential to keep in mind that while HCG levels provide valuable information, they are just one piece of the puzzle. The rate at which HCG levels double is often a good indicator of a healthy pregnancy. Typically, HCG levels should double approximately every 48 to 72 hours in early pregnancy. If your levels are rising but not doubling as expected, it may warrant further investigation.

Additionally, it is worth noting that the presence of PCOS can lead to a higher risk of miscarriage and other complications during pregnancy. Therefore, close monitoring by your healthcare provider is vital. They may recommend additional tests, such as ultrasounds, to assess the status of the pregnancy and ensure that everything is progressing as it should.

In summary, while your initial HCG level of 14.5 mUI/ml indicates the possibility of pregnancy, the follow-up tests will provide more clarity. It is essential to monitor the trends in your HCG levels and consult with your healthcare provider regarding any concerns. Given the complexities associated with PCOS, maintaining open communication with your doctor and following their recommendations will be crucial as you navigate this journey.

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