Can Ovulation Pills and Progesterone Delay Your Period? - Obstetrics and Gynecology

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Taking ovulation medications and progesterone can cause irregular menstrual cycles?


Hello, my last menstrual period was from August 24 to 29.
I visited a gynecologist for menstrual regulation in the previous two months.
During my August follow-up, I informed the doctor that I was trying to conceive.
The doctor prescribed ovulation medication and provided information about the ovulation timing and optimal intercourse timing.
After that, I also took medication to support implantation.
On September 25, during my follow-up, the doctor performed a urine test which showed only one line, indicating that my period should be coming soon.
However, today is September 30, and my period still hasn't arrived, although I am experiencing some cramping in my lower abdomen.
I would like to know if taking ovulation medication and progesterone could delay my period, as my menstrual cycles were very regular when I took menstrual regulation medication in the previous two months.

Mickey, 30~39 year old female. Ask Date: 2020/09/30

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it's generally not a concern.
Wait for another week, and if it still doesn't come, I recommend seeing a gynecologist.
Wishing you good health.

Reply Date: 2020/09/30

More Info


When considering the use of ovulation pills and progesterone (such as Provera) to delay your period, it's essential to understand how these medications work and their potential effects on your menstrual cycle.
Ovulation pills, often containing hormones like clomiphene citrate or letrozole, are primarily used to stimulate ovulation in women who may have difficulty conceiving. These medications work by influencing the hormonal signals that regulate the menstrual cycle, thereby promoting the development and release of eggs from the ovaries. On the other hand, progesterone is a hormone that plays a crucial role in regulating the menstrual cycle and maintaining pregnancy. It is often prescribed to help prepare the uterine lining for a potential pregnancy and to support early pregnancy if conception occurs.

In your case, you mentioned that you have been taking ovulation pills and progesterone while preparing for pregnancy. If your menstrual cycle has been regular in the past and you are now experiencing a delay, it could be due to several factors, including the hormonal influence of the medications you are taking.
Progesterone can indeed delay the onset of menstruation. When taken in the luteal phase of the cycle, it helps maintain the uterine lining, preventing the shedding that occurs during menstruation. If you are taking progesterone and have not yet conceived, your body may be responding to the hormone by delaying your period. This is a common effect of progesterone therapy, especially if it is taken in the days leading up to when your period would typically start.

However, it is also important to consider that the absence of menstruation could indicate pregnancy, especially if you have been actively trying to conceive. The symptoms you described, such as lower abdominal cramping, could be related to hormonal changes or early signs of pregnancy. If your period does not arrive soon, it would be advisable to take a home pregnancy test or consult with your healthcare provider for further evaluation.

In summary, taking ovulation pills and progesterone can potentially delay your period due to their hormonal effects. If you are concerned about the delay or if you suspect you may be pregnant, it is best to consult with your healthcare provider for personalized advice and to discuss the next steps. They can provide guidance on whether to continue the current medications or if any adjustments are necessary based on your specific situation.

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