Fibrocystic Breasts and SSRI: Risks and Side Effects - Breast and Thyroid

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Fibrocystic changes and SSRIs (Selective Serotonin Reuptake Inhibitors)


Hello Doctor, I have been diagnosed with obsessive-compulsive disorder by a psychiatrist and am currently taking an SSRI, specifically 100 mg per day (50 mg twice a day).
I have multiple fibrocystic breast changes on both sides, which are monitored with regular ultrasounds.
Since starting the medication, I have experienced nipple tenderness beginning in the second week, and I found online that this could be a side effect of SSRIs.
I would like to ask if this increases the risk of breast cancer or if it could lead to more cysts forming.
Is there a need to change my medication? I have discussed the fibrocystic changes with my psychiatrist, but at that time, I did not have any nipple pain.
Thank you for your guidance.

Ivy, 40~49 year old female. Ask Date: 2020/10/05

Dr. Yuan Tianmin reply Breast and Thyroid


Current studies suggest that breast cancer may be influenced by SSRIs, but this is not a definitive conclusion.

Reply Date: 2020/10/05

More Info


When it comes to the relationship between selective serotonin reuptake inhibitors (SSRIs) and fibrocystic breast changes, it is essential to understand both the potential side effects of SSRIs and the nature of fibrocystic breast disease. Fibrocystic breast changes are common and characterized by the presence of lumps or cysts in the breast tissue, often accompanied by tenderness or pain, particularly in relation to hormonal fluctuations during the menstrual cycle.

Firstly, SSRIs, which are commonly prescribed for conditions such as anxiety and obsessive-compulsive disorder, can indeed have side effects that include breast tenderness or pain. This is not uncommon and can be attributed to the way SSRIs affect serotonin levels in the body, which can influence various bodily functions, including hormonal balance. However, while breast tenderness may be a side effect, there is currently no conclusive evidence that SSRIs increase the risk of breast cancer or exacerbate the development of fibrocystic breast changes.
Research on the relationship between SSRIs and breast cancer risk has produced mixed results. Some studies suggest that SSRIs may have a protective effect against certain types of cancer, while others indicate no significant correlation. It is crucial to note that most of the studies conducted have not definitively established a causal link between SSRIs and an increased risk of breast cancer. Therefore, while it is understandable to be concerned about the potential risks associated with medication, the current consensus in the medical community is that SSRIs do not significantly increase breast cancer risk.

Regarding the concern about the development of more cysts or lumps in the breast, SSRIs are not known to directly cause an increase in the number of fibrocystic changes. However, if you are experiencing new symptoms such as breast tenderness, it is advisable to discuss these changes with your prescribing physician. They may consider adjusting your medication or exploring alternative treatments if the side effects are bothersome or concerning.

If you are currently under regular ultrasound monitoring for your fibrocystic breasts, it is essential to continue these follow-ups. Regular monitoring can help ensure that any changes in your breast tissue are appropriately evaluated. If you notice any new lumps or changes in your breast tissue, it is crucial to report these to your healthcare provider promptly.

In conclusion, while SSRIs can cause breast tenderness as a side effect, there is no strong evidence linking them to an increased risk of breast cancer or the exacerbation of fibrocystic breast changes. It is always best to maintain open communication with your healthcare provider regarding any new symptoms or concerns you may have while on medication. They can provide personalized advice and determine the best course of action based on your specific situation. If necessary, they may suggest alternative treatments that could alleviate your symptoms without compromising your mental health treatment.

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