Lumps on Thigh: Possible Lymphadenopathy Concerns - Oncology

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Swelling in the thigh suspected to be lymphadenopathy?


Hello Dr.
Chen, around September 25th, I experienced lower back pain, thinking it would improve, but I only went for a consultation on October 1st.
The diagnosis was sciatica, and one day I felt pain radiating to the left side of my abdomen.
On October 4th, while at work, I felt pain in my left thigh when it was resting against the desk for two consecutive days; it felt tight and strange when pressed (due to my work, I often lean against a low table).
I initially thought it was a bruise, but upon examination, there were no visible abnormalities.

On October 6th, I touched the painful area on my left thigh, close to the groin (not on the inner or outer side, but towards the front near the inner thigh).
I felt a semi-circular mass that seemed to be about 2 centimeters.
On October 8th, I visited a dermatologist, and while standing for the doctor to examine me, the doctor mentioned that it felt like enlarged lymph nodes, and there were quite a few of them (which surprised me).
The doctor asked if I had any other infections (it seemed to be related to gynecological issues), and I said no (I had forgotten that my back pain had mostly subsided by then).
The doctor mentioned it could potentially be something concerning, and if it doesn’t resolve, one might need to excise a node for testing.
I was prescribed anti-inflammatory and pain relief medication.
After returning home, I found 1 or 2 other lumps that also felt smooth on the surface; pressing on them caused pain, while the oval-shaped one did not hurt.
My back pain has almost completely resolved (only slightly painful with certain movements), but the lumps remain (I occasionally press on them).
I would like to inquire how long it typically takes for enlarged lymph nodes to decrease in size with anti-inflammatory medication.
If they do not resolve, which specialty should I consult for treatment? Is it oncology? Are there any out-of-pocket expenses I should be aware of? Thank you very much, Doctor.
(Additional note: The lumps feel like they are not attached to the skin, seem not very hard, but are in a fixed location, and should have smooth surfaces.)

Miss Wang, 20~29 year old female. Ask Date: 2020/10/10

Dr. Chen Yunfang reply Oncology


Hello: If the lump does not disappear or decrease in size after two weeks, please see a hematologist or a general surgeon.
If the doctor finds anything unusual, they will arrange for a lymph node biopsy.
Thank you.

Reply Date: 2020/10/10

More Info


Understanding lumps on the thigh, particularly in the context of possible lymphadenopathy, can be concerning and warrants careful evaluation. Based on your description, it seems you have experienced some discomfort in your left thigh, which led to the discovery of a lump that your dermatologist suspects may be an enlarged lymph node.
Lymphadenopathy refers to the enlargement of lymph nodes, which can occur for various reasons, including infections, inflammatory conditions, or malignancies. In your case, the lump you described is approximately 2 cm in size and is located near the groin area, which is a common site for lymph nodes. The fact that the lump is smooth and not fixed to the skin is a positive sign, as it may indicate that it is not a malignant tumor. However, the presence of multiple lumps and the pain you experienced when pressing on them should not be overlooked.

When it comes to the treatment of lymphadenopathy, the course of action often depends on the underlying cause. If the enlargement is due to an infection, anti-inflammatory medications or antibiotics may help reduce the swelling. You mentioned that you were prescribed anti-inflammatory pain medication, which can alleviate discomfort but may not directly address the underlying cause of the lymphadenopathy.

Typically, if the lymph nodes do not decrease in size after a few weeks of treatment, further evaluation is warranted. This may include imaging studies, such as an ultrasound or CT scan, to assess the lymph nodes' characteristics and rule out any serious conditions. If there is still concern about malignancy or if the lymph nodes remain enlarged, a biopsy may be necessary to obtain a definitive diagnosis.

In terms of which specialist to consult, if the lymphadenopathy persists, it would be appropriate to see a hematologist or an oncologist, as they specialize in blood disorders and cancers, including lymphatic system issues. They can provide a more comprehensive evaluation and determine if any further testing or treatment is needed.

As for your question about the duration for the lymph nodes to resolve with anti-inflammatory medication, it can vary widely depending on the underlying cause. If the lymphadenopathy is due to a benign condition, it may resolve within a few weeks. However, if it is related to a more serious issue, it may take longer or require additional intervention.

In summary, while the presence of lumps in the thigh can be alarming, many cases of lymphadenopathy are benign and resolve with appropriate treatment. However, it is crucial to monitor the situation closely and follow up with your healthcare provider if the lumps do not decrease in size or if you develop new symptoms. Keeping an open line of communication with your doctor and addressing any concerns you have is essential for your peace of mind and health.

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