Skin Whitening from Steroid Cream Use in Genital Area - Internal Medicine

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The use of steroid ointments has caused depigmentation of the genital skin?


Hello, doctor.
I have a few questions.
Due to prostatitis, I am experiencing itching and moisture in the scrotum, burning at the urethral opening, and burning on the glans.
I applied a steroid ointment (Betamethasone asproptionate 0.5mg/10gm from Renren Pharmaceutical) on my scrotum, glans, and penis, which alleviated the itching.
However, the next day, the skin under the glans turned white, and I have stopped using the medication out of concern.

1) What could be the cause of the white skin?
2) Will the white skin lead to irreversible skin changes?
3) How can I restore the skin to its original state, and how long will it take?
4) If there are no changes, will the skin permanently remain lighter in color? Should I see a doctor to address the white skin condition, or is it okay to leave it alone?
5) Should I treat the prostatitis and the skin itching issues simultaneously for a complete recovery? I would greatly appreciate your guidance.
Thank you.

Can, 40~49 year old female. Ask Date: 2020/10/22

Dr. Zeng Guosen reply Internal Medicine


Hello, it is unlikely that the use of steroid ointments would cause skin discoloration in just a day or two.
The cause of your condition is unclear, so I recommend returning to your original healthcare provider or visiting a dermatologist for evaluation.
Thank you for your question.

Reply Date: 2020/10/22

More Info


When it comes to the use of topical steroids, such as Betamethasone, particularly in sensitive areas like the genital region, there are several important considerations regarding skin changes and potential side effects. Your concerns about the whitening of the skin after using the steroid cream are valid and warrant a thorough understanding.

1. Why is the skin white? The whitening of the skin you observed could be due to several factors. One possibility is that the steroid cream has caused a condition known as hypopigmentation, where the skin loses its pigment. This can happen with prolonged use of topical steroids, especially in sensitive areas. Additionally, the skin may appear lighter due to the thinning of the epidermis, which is a common side effect of long-term steroid use. Steroids can also alter the skin's barrier function, leading to changes in moisture retention and pigmentation.

2. Will the white skin cause irreversible skin changes? The potential for irreversible changes largely depends on the duration and potency of the steroid used, as well as individual skin response. In many cases, if the steroid use is discontinued and the skin is allowed to heal, normal pigmentation may gradually return. However, in some instances, particularly with prolonged use, there may be lasting changes. It is crucial to monitor the area and consult a dermatologist for a professional evaluation.

3. How to restore the skin to its original state? To help restore your skin, it is advisable to stop using the steroid cream immediately, as you have done. Instead, consider using a gentle moisturizer to support the skin barrier. Products containing ingredients like ceramides or hyaluronic acid can be beneficial. Additionally, sun protection is essential, as UV exposure can exacerbate pigmentation issues. The time it takes for the skin to return to its normal color can vary widely, from weeks to months, depending on individual healing processes and skin type.

4. Will the skin permanently remain white? If the skin has not sustained significant damage, there is a good chance that the pigmentation will return to normal over time. However, if the hypopigmentation persists, it may require treatment. Consulting a dermatologist can provide you with tailored advice and potential treatment options, such as topical agents that promote pigmentation or laser therapies.

5. Should the prostatitis and skin issues be treated together? Yes, addressing the underlying cause of your symptoms, such as prostatitis, is important. If the inflammation and irritation in the genital area are resolved, it may help alleviate the skin issues as well. A comprehensive approach that includes both dermatological care and treatment for prostatitis will likely yield the best results.

In summary, while the whitening of the skin following steroid use can be concerning, it is often reversible with appropriate care. It is advisable to consult with a dermatologist who can assess your specific situation and recommend a suitable treatment plan. They can also help monitor any changes in your skin and ensure that any underlying conditions, like prostatitis, are effectively managed. Remember, self-treatment can sometimes lead to complications, so professional guidance is always the best route.

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