Long-Term Birth Control Pills: Do You Need Liver and Kidney Function Tests? - Obstetrics and Gynecology

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Long-term use of contraceptive pills?


Hello Doctor: Due to having polycystic ovary syndrome, my doctor recommended that I purchase birth control pills to regulate my menstrual cycle.
I have been taking the birth control pills for almost 2 years without stopping, and aside from experiencing migraine symptoms, I have no other discomfort.
I would like to know if I need to have tests done for liver and kidney function or cholesterol levels.
Thank you for taking the time to respond!

Miss Yang, 20~29 year old female. Ask Date: 2020/11/06

Dr. Zhang Kunmin reply Obstetrics and Gynecology


Hello, the common side effects of oral contraceptives include: headaches, dizziness, heavy or irregular menstrual bleeding, nausea, vomiting, edema, increased cervical mucus, cervical hypertrophy, increased appetite, weight gain, skin itching, acne, fatigue, depression, flushing, feelings of weakness, breast tenderness, and increased risk of yeast infections, among others.

Groups that are not suitable for using oral contraceptives include:
- Pregnancy
- Breast cancer
- Circulatory diseases (venous or arterial thrombosis, ischemic heart disease, cerebral hemorrhage)
- Coagulation disorders with a tendency to thrombosis
- Liver disease
- Systemic lupus erythematosus, hemolytic uremic syndrome
- Smokers over the age of 35
- Hypertension (blood pressure over 140/90 mmHg), diabetes
If you experience any related side effects or have concerns, please consult a physician for evaluation.
Thank you! Wishing you safety and health.

Dr.
Chang

Reply Date: 2020/11/06

More Info


When it comes to long-term use of birth control pills, particularly in the context of polycystic ovary syndrome (PCOS), it is essential to consider the potential impact on liver and kidney function, as well as lipid profiles. While many women use hormonal contraceptives without significant issues, regular monitoring can help ensure that any potential side effects are caught early.


Liver Function Tests
Hormonal contraceptives, especially those containing estrogen, can have an impact on liver function. Although serious liver complications are rare, they can occur, particularly in women with pre-existing liver conditions or risk factors. Therefore, it is advisable to have liver function tests (LFTs) periodically, especially if you have been on the pill for an extended period, such as two years in your case. These tests typically measure enzymes like alanine aminotransferase (ALT) and aspartate aminotransferase (AST), which can indicate liver inflammation or damage.


Kidney Function Tests
While the direct impact of birth control pills on kidney function is less pronounced compared to liver function, it is still prudent to monitor kidney health, especially if you have other risk factors such as hypertension or diabetes. Kidney function tests, including serum creatinine and blood urea nitrogen (BUN), can provide valuable insights into your renal health.


Lipid Profile
Long-term use of hormonal contraceptives can also affect lipid metabolism. Some studies suggest that estrogen can lead to changes in cholesterol levels, potentially increasing the risk of cardiovascular disease. Therefore, it is a good idea to have a lipid profile done periodically to monitor your cholesterol levels, particularly if you have other risk factors for heart disease.


Headaches and Other Symptoms
You mentioned experiencing migraines while on the pill. Migraines can be exacerbated by hormonal changes, and in some cases, the type of birth control pill may need to be adjusted. If your headaches are severe or worsening, it would be wise to consult your healthcare provider. They may recommend switching to a different formulation or exploring other treatment options for your migraines.


Recommendations
1. Regular Check-ups: It is advisable to have regular check-ups with your healthcare provider, including liver and kidney function tests, as well as a lipid profile, especially given your long-term use of birth control pills.


2. Monitor Symptoms: Keep track of any new or worsening symptoms, such as headaches, changes in mood, or any signs of liver dysfunction (like jaundice or abdominal pain). Report these to your doctor promptly.

3. Lifestyle Considerations: Maintain a healthy lifestyle, including a balanced diet and regular exercise, which can help mitigate some risks associated with long-term hormonal contraceptive use.

4. Discuss Alternatives: If you are concerned about the long-term effects of the pill, discuss alternative contraceptive methods with your healthcare provider. There are various options available, including non-hormonal methods.

In conclusion, while long-term use of birth control pills is generally safe for many women, regular monitoring of liver and kidney function, as well as lipid levels, is advisable. This proactive approach can help ensure your overall health and well-being while managing conditions like PCOS. Always consult with your healthcare provider for personalized advice and recommendations based on your specific health needs.

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