Drug Interactions with Birth Control Pills: Key Insights - Obstetrics and Gynecology

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Drug interactions


Hello, doctor.
I recently started taking the contraceptive pill, Nina film-coated tablets, which contain Estradiol 0.035mg and Cyproterone 2mg per tablet, starting from November 2nd.
I have three questions:
1.
On the night of November 6th, I took some sleep aids, specifically VANCONIN TABLETS 5MG (active ingredient: DIAZEPAM), Fluronin Capsules 20mg (active ingredient: Fluoxetine), and LENDORMIN 0.25MG TABLETS (active ingredient: BROTIZOLAM).
Will these medications affect the effectiveness of the contraceptive pill? Could they render the contraceptive pill ineffective?
2.
How long after starting the pill should I wait before it becomes effective? If I have a steady partner, can we have intercourse without using condoms?
3.
I take the contraceptive pill every night before bed, but the timing varies—sometimes at 11:30, 12:30, or 1:00.
Is it necessary to take it at a consistent time each day, or is my current method acceptable?
Thank you very much for your help! 🙏🥺🥺

Shan Shan, 20~29 year old female. Ask Date: 2020/11/09

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, generally it does not have an impact.
If you take the medication on time, it will be effective for contraception, and there should be no need to use condoms.
Just take it around the same time.
Wishing you good health.

Reply Date: 2020/11/09

More Info


When it comes to understanding drug interactions with birth control pills, it's essential to consider how various medications can affect the efficacy of contraceptives and the overall health of the individual. Let's address your questions one by one.

1. Impact of Sleep Medications on Birth Control Pills: The medications you mentioned—VANCONIN (Diazepam), Prozac (Fluoxetine), and LENDORMIN (Brotizolam)—are primarily used for anxiety, depression, and sleep disorders. Generally, these medications do not significantly affect the efficacy of hormonal contraceptives like the Nina pill (Estradiol + Cyproterone). However, certain medications can interact with birth control pills, particularly some antibiotics and anti-seizure medications. Diazepam and Fluoxetine are not known to reduce the effectiveness of birth control pills. Therefore, you should not worry about these medications making your birth control ineffective.

2. Timing for Contraceptive Effectiveness: Birth control pills typically require a few days to become effective, depending on when you start taking them. If you start taking the pill during the first five days of your menstrual cycle, you are protected from pregnancy immediately. If you start taking it at another time, it usually takes about seven days for the pill to become effective. Since you mentioned starting the pill on November 2nd, if you began it during your menstrual cycle, you should be protected by November 6th. If you started it at another time, consider using backup contraception (like condoms) for the first week.

3. Consistency in Taking Birth Control Pills: It is crucial to take your birth control pill at the same time every day to maintain consistent hormone levels in your body. While a few hours of variation may not significantly impact the effectiveness, it is best to establish a routine. If you find it challenging to take the pill at the same time every day, consider setting an alarm or associating it with another daily activity (like brushing your teeth) to help you remember. If you miss a dose, follow the instructions provided with your medication, which usually advise taking the missed pill as soon as you remember and continuing with your regular schedule.

In summary, the medications you are taking for sleep and anxiety should not interfere with the effectiveness of your birth control pill. Ensure you start the pill correctly based on your menstrual cycle, and aim to take it at the same time each day for optimal effectiveness. If you have any further concerns or experience any unusual symptoms, it is always best to consult with your healthcare provider for personalized advice.

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