Should You Get a Hepatitis B Vaccine Boost? Conflicting Medical Opinions Explained - Gastroenterology and Hepatology

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Should hepatitis B vaccination be administered or not?


Hello Doctor, my husband is a carrier of hepatitis B and his levels are often high.
In November 2019, I tested: HBsAg negative at 0.40 COI, and anti-HBs positive at 41.5.
At that time, Doctor A advised me to receive the vaccine, but due to other commitments, I only received one dose and did not return for the others.
In October 2020, my husband's levels spiked again, and while accompanying him during his medical visit, I was concerned about not having received the last two doses.
However, Doctor B later told me that I did not need to receive the vaccine again, and that the initial vaccination was unnecessary.
He then retested me, and my HBsAg was 0.38.
Doctor A mentioned that antibodies can diminish over time and that having a higher level is better.
Doctor B stated that having antibodies means I have them, and there is no need for further vaccination.
However, I found information suggesting that it is best to have levels above 50 or 100, and my initial level of 41.5 seems low.
Since the two doctors have differing opinions, I am now unsure whether I should receive additional vaccinations.

Ms. Z, 40~49 year old female. Ask Date: 2020/11/10

Dr. Chen Shidian reply Gastroenterology and Hepatology


If you don't mind/for the highest standard, administer one dose, then measure antibody levels after one month.
After that, test every 2-3 years, and if the levels decrease, administer another dose, following the practices of healthcare workers.

Reply Date: 2020/11/10

More Info


When it comes to the question of whether you should get a Hepatitis B vaccine boost, especially in the context of being in close contact with a Hepatitis B carrier, the medical opinions can indeed be conflicting. Let's break down the situation and the relevant medical knowledge surrounding it.

Firstly, Hepatitis B is a viral infection that can lead to serious liver problems, including chronic liver disease and liver cancer. Vaccination is a key preventive measure against Hepatitis B. The standard vaccination schedule consists of three doses, and it is generally effective in providing long-term immunity. However, the presence of antibodies (anti-HBs) in your blood is what indicates immunity.

In your case, you mentioned that your anti-HBs level was 41.5 mIU/mL. While this level indicates that you have some immunity, it is indeed lower than the optimal protective levels, which are often considered to be above 100 mIU/mL. The concern raised by Dr. A regarding the potential waning of antibodies over time is valid; immunity can diminish, especially if the initial antibody response was not robust.

Dr. B's assertion that having any detectable level of anti-HBs means you are protected is also a common perspective. However, the reality is that while you may have some level of protection, it may not be sufficient, especially considering your husband's active Hepatitis B infection. The risk of exposure to the virus in your household could warrant a more proactive approach to ensure your immunity is at a protective level.

The Centers for Disease Control and Prevention (CDC) recommends that individuals who are at increased risk for Hepatitis B, such as those living with an infected person, should consider booster doses if their anti-HBs levels fall below 10 mIU/mL. Given that your level is above this threshold but still on the lower side, it may be prudent to discuss with your healthcare provider the possibility of receiving a booster dose to enhance your immunity.

In terms of safety, the Hepatitis B vaccine is generally well-tolerated, and the risk of adverse effects is low. The vaccine cannot cause Hepatitis B infection, as it contains only a part of the virus (the surface antigen) and not the live virus itself. Therefore, concerns about getting infected from the vaccine are unfounded.

Ultimately, the decision to receive a booster dose should be made in consultation with your healthcare provider, taking into account your specific circumstances, including your exposure risk and your current antibody levels. If you decide to get a booster, it can help ensure that your immunity is robust enough to protect you against potential exposure to Hepatitis B.

In summary, while both doctors have valid points, the best course of action may be to err on the side of caution, especially given your husband's condition. A booster could provide additional protection and peace of mind. Regular monitoring of your antibody levels can also help guide future vaccination decisions. Always keep an open line of communication with your healthcare provider to ensure that your health needs are being met effectively.

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