Does Oral A Acid Cause Cysts? Skin Reactions - Dermatology

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Does taking oral isotretinoin cause cysts?


Hello, doctor.
When the physician prescribed me oral isotretinoin, they mentioned that I might experience breakouts in one to two weeks.
Is it possible for cysts to appear as a result of taking oral isotretinoin? Thank you.

AL, 30~39 year old female. Ask Date: 2020/12/25

Dr. Wu Yuxin reply Dermatology


Usually not.

Reply Date: 2020/12/25

More Info


Oral A Acid, commonly known as isotretinoin, is a powerful medication primarily used to treat severe acne. It works by reducing the size and activity of sebaceous glands, leading to decreased oil production and, consequently, fewer acne lesions. However, the initiation of isotretinoin treatment can sometimes lead to an initial worsening of acne, often referred to as the "purging" phase. This phenomenon occurs because isotretinoin accelerates the turnover of skin cells, which can cause existing comedones (clogged pores) to become inflamed and emerge as acne lesions.

Regarding your question about cysts, it is important to clarify that while isotretinoin is effective in treating cystic acne, it does not directly cause cysts. Instead, the medication can lead to the formation of new acne lesions, including cysts, during the initial weeks of treatment as the skin adjusts to the medication. This is particularly true if the skin is already prone to acne or if there are underlying issues that have not been addressed prior to starting treatment.

Cysts, or sebaceous cysts, are typically formed when a hair follicle becomes clogged with sebum and dead skin cells. While isotretinoin reduces the overall oil production, it does not eliminate the possibility of cyst formation, especially if there are pre-existing conditions or if the skin is undergoing significant changes.
In your case, if you are experiencing new cysts after starting isotretinoin, it is essential to monitor their progression. If they are painful, inflamed, or not responding to treatment, it would be advisable to consult your dermatologist. They can assess whether these cysts are a result of the medication or if there is another underlying issue that needs to be addressed.

Additionally, it is crucial to maintain open communication with your healthcare provider about any side effects or concerns you may have during your treatment. Isotretinoin can have various side effects, including dryness of the skin, lips, and mucous membranes, which can sometimes lead to irritation and exacerbate existing skin conditions.
To manage the side effects of isotretinoin, consider the following recommendations:
1. Hydration: Keep your skin well-hydrated using non-comedogenic moisturizers. This can help alleviate dryness and irritation.

2. Gentle Skin Care: Use mild, non-irritating cleansers and avoid harsh scrubs or exfoliants that can further irritate the skin.

3. Sun Protection: Isotretinoin can increase your skin's sensitivity to sunlight, so applying a broad-spectrum sunscreen daily is essential.

4. Follow-Up Appointments: Regular follow-ups with your dermatologist are crucial to monitor your progress and adjust the treatment plan as necessary.

In summary, while isotretinoin can lead to an initial worsening of acne, including the potential for cyst formation, it is not a direct cause of cysts. If you have concerns about new cysts or any other skin reactions during your treatment, it is best to consult your dermatologist for personalized advice and management strategies.

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