Mycoplasma and Atypical Infections: Symptoms and Treatments - Pulmonology

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Please provide information regarding bronchial Mycobacterium or atypical infections (such as key errors if applicable)?


Hello Dr.
Ke, I had a cold at the end of last year, and since then I have been experiencing intermittent coughing that persists to this day.
The cough worsens in cold weather.
A doctor at the Air Force General Hospital mentioned that this could be due to Mycoplasma or an atypical infection, and prescribed erythromycin.
However, my symptoms have become quite severe, and I am very distressed.
Could you please advise me on the infectious nature of this condition and the treatment options? Thank you!

Li, 30~39 year old female. Ask Date: 2003/02/04

Dr. Ke Zhengchang reply Pulmonology


Coughing after a cold can persist for a period of time.
Patients with asthma may experience exacerbations, leading to prolonged coughing.
Therefore, administering erythromycin may not necessarily be effective.
It is recommended to consult a pulmonologist for further evaluation and examination, including X-rays and pulmonary function tests.

Reply Date: 2003/02/04

More Info


Mycoplasma infections, particularly those caused by Mycoplasma pneumoniae, are a common cause of atypical pneumonia, especially in younger populations. These infections can lead to a variety of respiratory symptoms, including a persistent cough, which can last for weeks or even months after the initial infection has resolved. The cough is often dry and can be accompanied by other symptoms such as fever, malaise, and sometimes chest pain.
Mycoplasma pneumoniae is unique because it lacks a cell wall, making it resistant to many common antibiotics that target bacterial cell walls, such as penicillin. Instead, macrolides (like erythromycin), tetracyclines (like doxycycline), and fluoroquinolones are typically used to treat these infections. In your case, erythromycin was prescribed, which is appropriate for treating Mycoplasma pneumoniae. However, if your symptoms have worsened or have not improved significantly, it may indicate that the infection is either more severe than initially thought or that there is a co-infection with another pathogen.

Transmission of Mycoplasma pneumoniae occurs through respiratory droplets when an infected person coughs or sneezes. It is important to note that while these infections can spread from person to person, they are generally not as contagious as other respiratory infections, such as influenza or COVID-19.
In terms of treatment, if erythromycin is not effective, your healthcare provider may consider switching to another antibiotic that is effective against Mycoplasma, such as doxycycline or azithromycin. Additionally, supportive care is crucial. This includes staying hydrated, using cough suppressants if necessary, and possibly using bronchodilators if wheezing or difficulty breathing is present.

If your cough persists despite treatment, it may be worthwhile to investigate other potential causes. Chronic cough can result from various factors, including postnasal drip, asthma, gastroesophageal reflux disease (GERD), or even other infections. A thorough evaluation by a healthcare provider, including a physical examination and possibly imaging studies or pulmonary function tests, may be warranted to rule out these conditions.

In summary, Mycoplasma pneumoniae can cause a persistent cough and atypical pneumonia, and while it is transmissible, it is less contagious than many other respiratory infections. Treatment typically involves macrolides or tetracyclines, and if symptoms worsen or do not improve, further evaluation and possibly a change in antibiotic therapy may be necessary. Always consult with your healthcare provider for personalized medical advice and treatment options.

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