Ultrasound and CA125 Results in Endometriosis Diagnosis - Obstetrics and Gynecology

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Regarding the results of ultrasound and CA-125 testing?


Hello Doctor, I apologize for the lengthy message and thank you for your response.
(I have not engaged in sexual intercourse yet) I have been experiencing chronic menstrual pain, which I used to endure, but over the past six months, the pain has become increasingly severe (I often wake up at night due to pain during the first two days of my period).
This is accompanied by pain in the rectal area, coccyx, and lower back.
Pain relievers have not been effective.
Recently, I consulted with Dr.
A, a gynecologist, who diagnosed me with endometriosis.
Dr.
B (the deputy director) said the ultrasound was normal and advised me to wait for the CA125 report.
Dr.
C indicated that I have endometriosis and suspected adenomyosis, and my CA125 level was 440, which is abnormal.
He advised me to retest (the second test showed 493).
However, since Dr.
C and Dr.
B are from the same hospital, he asked me to return to Dr.
B for follow-up.
It has been over a week since my last period ended, and while the discomfort has lessened, it still persists.
When I returned to see Dr.
B, he mentioned that the initial tests were conducted while I was still experiencing menstrual pain, so those results were not significant.
He advised me to wait until I am not in pain to undergo further testing.
Regarding the endometriosis, he mentioned that I could choose to take medication or pay for menopause-inducing injections.
I would like to ask the doctor: (1) Is Dr.
B's statement accurate? If so, why were the tests arranged at that time? (2) For the discomfort in the lower abdomen, near the vaginal opening, rectum, coccyx, and lower back, do I just have to wait until the pain subsides? (Especially the sharp pain in the rectum and coccyx, which has been almost constant.) (3) Besides medication and self-funded injections, are there any other treatment options available?

A Fang, 30~39 year old female. Ask Date: 2021/01/16

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, some issues are difficult to address, so I recommend getting checked at another hospital.
Wishing you good health.

Reply Date: 2021/01/16

More Info


Understanding the results of ultrasound and CA-125 tests in the context of endometriosis can be quite complex, especially given the symptoms you've described and the varying opinions from different doctors. Let’s break down your concerns and provide some clarity.


1. Understanding CA-125 Levels and Their Implications
CA-125 is a protein that is often elevated in women with endometriosis, pelvic inflammatory disease, and certain cancers, particularly ovarian cancer. A normal CA-125 level is typically considered to be below 35 U/mL. Your levels of 440 and then 493 are significantly elevated and warrant further investigation. However, it is important to note that CA-125 is not a definitive diagnostic tool for endometriosis; it is more of a marker that can indicate the presence of a problem.

B doctor’s statement that your CA-125 results may not be valid due to the presence of pain during testing is somewhat misleading. While it is true that pain can influence the interpretation of results, CA-125 levels can remain elevated regardless of the timing of the test in relation to your menstrual cycle. Therefore, it is crucial to consider these results in conjunction with your symptoms and other diagnostic tests.


2. Addressing Your Symptoms
The discomfort you are experiencing in your lower abdomen, rectal area, tailbone, and lower back is concerning, especially since it has been persistent and severe. While it may feel like you have to wait until the pain subsides to seek further help, this is not the best approach. Chronic pain, especially when it interferes with daily life, should be addressed actively.
You should consider discussing your symptoms with your healthcare provider again, emphasizing the impact they have on your quality of life. There are various management strategies for endometriosis, including hormonal treatments, pain management options, and potentially surgical interventions if necessary.

3. Treatment Options Beyond Medication
In addition to hormonal treatments and pain management, there are several other approaches to consider:
- Lifestyle Modifications: Diet, exercise, and stress management can play a significant role in managing endometriosis symptoms. Some women find relief through anti-inflammatory diets or regular physical activity.

- Physical Therapy: Pelvic floor physical therapy can help alleviate pain associated with endometriosis, particularly if there is pelvic floor dysfunction.

- Surgical Options: If your symptoms are severe and not responding to medication, surgical options may be considered. This could involve laparoscopic surgery to remove endometrial tissue or cysts.

- Alternative Therapies: Some women find relief through acupuncture, herbal supplements, or other complementary therapies. However, it is essential to discuss these options with your healthcare provider to ensure they are safe and appropriate for your situation.


Conclusion
In summary, while CA-125 levels and ultrasound findings are important in the diagnosis and management of endometriosis, they should be interpreted in the context of your symptoms and overall health. It is crucial to advocate for yourself and seek further evaluation and treatment options that address your pain and improve your quality of life. Don’t hesitate to seek a second opinion if you feel your concerns are not being adequately addressed. Your health and comfort are paramount, and there are various avenues to explore for relief from your symptoms.

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