Long-Acting Oral Contraceptives: Safety and Efficacy Concerns

Regarding long-acting oral contraceptives?

Dear Doctor, my girlfriend recently purchased a so-called long-acting oral contraceptive: ROSA (containing Levonorgestrel 6mg and Quinestrol 3mg).
The pharmacy in France stated that it only needs to be taken once a month, which is why she found it convenient and decided to buy it.
However, she has never heard of this type of contraceptive pill and is hesitant to take it.
Could you please advise if long-acting oral contraceptives have greater side effects on the body? I have heard that this type of contraceptive has not yet been approved in Taiwan, but it seems that similar medications are available in mainland China.
What could be the reason for this? Thank you, Doctor.

A-Hua, 20~29 year old female. Ask Date: 2003/02/04

Dr. Zhan Deqin reply Obstetrics and Gynecology

1.
The side effects of long-acting oral contraceptives may include a reduction in menstrual flow, and in some cases, menstruation may stop altogether; however, it often resumes after discontinuation of the medication.
2.
Taiwan has strict regulations regarding pharmaceuticals, so some products available in mainland China may not be available in Taiwan.
Thank you!

Reply Date: 2003/02/04

More Info

When it comes to long-acting oral contraceptives like ROSA, which contains Levonorgestrel and Quinestrol, there are several important factors to consider regarding their safety, efficacy, and potential side effects.
First, it’s essential to understand how these medications work. Levonorgestrel is a progestin, a synthetic form of the hormone progesterone, which helps prevent ovulation. Quinestrol, an estrogen, works in conjunction with Levonorgestrel to enhance contraceptive efficacy. The idea behind long-acting oral contraceptives is to simplify the regimen, allowing users to take the medication less frequently—once a month in this case—while still providing effective contraception.

Safety and Efficacy
The safety and efficacy of any contraceptive method depend on various factors, including the individual's health status, medical history, and lifestyle. Long-acting oral contraceptives can be effective, but they may also carry risks. Common side effects associated with hormonal contraceptives include:
1. Nausea and Vomiting: Some women may experience gastrointestinal discomfort when starting hormonal contraceptives.

2. Weight Changes: Hormonal fluctuations can lead to weight gain or loss.

3. Mood Changes: Hormonal contraceptives can affect mood and emotional well-being.

4. Breast Tenderness: Some women report breast discomfort when using hormonal contraceptives.

5. Increased Risk of Thrombosis: There is a potential risk of blood clots, especially in women who smoke, are over 35, or have a history of clotting disorders.

Long-Term Use and Monitoring
While long-acting oral contraceptives may seem convenient, it is crucial to monitor for any adverse effects, especially with long-term use. Regular check-ups with a healthcare provider can help manage any side effects and ensure that the contraceptive method remains suitable for the user.

Regulatory Differences
Regarding the regulatory status of such contraceptives, it’s important to note that different countries have varying standards for drug approval. In Taiwan, if ROSA has not been approved, it may be due to concerns about its safety profile, efficacy data, or the need for more extensive clinical trials to evaluate its long-term effects. In contrast, other countries, including those in mainland China, may have different regulatory frameworks that allow for the use of similar medications.

Recommendations
Before starting any new contraceptive method, including long-acting oral contraceptives, it is advisable for your girlfriend to consult with a healthcare provider. This consultation can help assess her individual health needs, discuss potential risks, and explore alternative contraceptive options if necessary.
Additionally, it’s essential to consider that while convenience is a significant factor in choosing a contraceptive method, the potential side effects and health implications should not be overlooked. A thorough discussion with a healthcare professional can provide clarity and help make an informed decision.

In summary, while long-acting oral contraceptives like ROSA can offer convenience, it’s vital to weigh the benefits against potential risks and side effects. Regular monitoring and consultation with a healthcare provider are crucial for ensuring safe and effective use of any hormonal contraceptive method.

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