Human T-Lymphotropic Virus Antibodies and Blood Donation Risks - Internal Medicine

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Currently, there is a blood donation activity, but after donating blood, I received a notification regarding a term on the form that I do not understand, which is "Human T-Lymphotropic Virus Type I and II Antibodies." I was informed that having this condition makes me unsuitable for blood donation, but I do not understand what this disease is or how one can become infected.
Could you please explain it to me?

Xiao Qiang, 30~39 year old female. Ask Date: 2003/02/10

Dr. Wang Fangli reply Internal Medicine


Hello, Xiaoqiang: Individuals who test positive for Human T-cell Lymphotropic Virus (HTLV) through serological examination are referred to as carriers.
Carriers are infectious and can transmit the virus to others through breast milk, blood, or bodily fluids.
Approximately 95% of HTLV carriers will never develop symptoms in their lifetime, while only 5% may develop Adult T-cell Leukemia and a related neurological disorder.

Reply Date: 2003/02/10

More Info


Human T-Lymphotropic Virus (HTLV) is a retrovirus that primarily affects T-lymphocytes, a type of white blood cell that plays a crucial role in the immune system. There are two main types of HTLV: HTLV-I and HTLV-II. HTLV-I is associated with several serious health conditions, including Adult T-cell Leukemia/Lymphoma (ATL) and HTLV-associated Myelopathy/Tropical Spastic Paraparesis (TSP/HAM). HTLV-II's pathogenic potential is less understood, but it is also associated with various health issues.

When you donate blood, your blood is screened for various infectious agents, including HTLV. If you test positive for HTLV antibodies, it indicates that you have been exposed to the virus at some point in your life. However, it is important to note that not everyone who tests positive will develop a disease. In fact, approximately 95% of HTLV carriers remain asymptomatic throughout their lives. Only about 5% of those infected will develop conditions related to the virus, and the incidence of these diseases is relatively low.

HTLV is primarily transmitted through blood, sexual contact, and from mother to child during childbirth or breastfeeding. This means that if you have a history of blood transfusions, sharing needles, or unprotected sexual intercourse, you may be at a higher risk of exposure. However, the virus is not transmitted through casual contact, such as hugging or sharing utensils.

Regarding your concern about blood donation, if you have tested positive for HTLV antibodies, it is standard practice for blood donation centers to defer you from donating blood. This is to protect the recipients of blood products from potential infection, as there is currently no effective antiviral treatment for HTLV, and the virus can persist in the body for a lifetime.

If you are worried about your health after receiving a positive test result for HTLV antibodies, it is advisable to consult with a healthcare provider who can perform further testing and provide guidance. The Western blot test is often used to confirm the presence of HTLV antibodies and to determine the specific type of HTLV you may have. This can help clarify your risk of developing associated diseases.

In terms of your recent blood donation experience and the body temperature of 37.4°C, it is generally not considered a fever, but it can indicate a mild inflammatory response. Mild elevations in body temperature can sometimes affect white blood cell counts, but they are unlikely to significantly impact the results of HTLV testing.

In conclusion, if you have tested positive for HTLV antibodies, it is essential to seek further medical evaluation to understand your health status better. While the presence of HTLV antibodies can be concerning, many individuals live healthy lives without developing any related diseases. Regular check-ups and monitoring can help manage any potential health risks associated with HTLV.

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