Is It Safe to Take Estrade During Early Pregnancy? - Obstetrics and Gynecology

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Medications during pregnancy


I am currently six weeks pregnant.
A few days ago, I experienced some light bleeding (pink discharge) and visited an obstetrician.
The doctor prescribed: Estrade 2mg, Utrogestan 100mg, Bokey, Eltroxin 50mcg, and Transamin 250mg.
Estrade is classified as a Category X medication for pregnancy.
Is it safe for me to take this? I found online that some pregnant women say it is used to thicken the endometrium and stabilize the embryo.
Should I take it or not?

mis, 30~39 year old female. Ask Date: 2021/01/29

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, if you have already taken progesterone, you may consider not taking it anymore.
Wishing you good health.

Reply Date: 2021/01/29

More Info


When it comes to taking medications during early pregnancy, particularly Estrade (estradiol), it is crucial to understand the implications and safety classifications associated with its use. Estrade is classified as a Category X medication by the FDA, which indicates that studies in animals or humans have demonstrated fetal abnormalities, and the risks involved in using the drug in pregnant women clearly outweigh any potential benefits. Therefore, it is generally advised to avoid using Estrade during pregnancy unless absolutely necessary and prescribed by a healthcare provider who is fully aware of your pregnancy status.

In your case, you mentioned experiencing some light pink discharge, which can be common in early pregnancy and may not necessarily indicate a serious problem. However, the prescription of Estrade raises concerns due to its classification. While some practitioners may prescribe it to help stabilize the uterine lining or support early pregnancy, the risks associated with its use during pregnancy cannot be overlooked. The potential for adverse effects on the developing fetus is significant, and thus, it is essential to weigh these risks against the benefits.

The other medications you mentioned—Utrogestan (progesterone), Bokey (levothyroxine), and Transamin (tranexamic acid)—also require careful consideration. Utrogestan is often used to support early pregnancy and may be beneficial in maintaining the pregnancy, especially if there are concerns about low progesterone levels. Levothyroxine is typically safe during pregnancy, as thyroid hormone levels need to be adequately maintained for both maternal and fetal health. However, Tranexamic acid is generally used to treat heavy bleeding and should be used cautiously in pregnancy.

Given the complexities surrounding medication use in early pregnancy, it is crucial to have an open dialogue with your healthcare provider. Discuss your concerns regarding the use of Estrade and any potential alternatives that may be safer for you and your baby. If your doctor believes that the benefits of taking Estrade outweigh the risks in your specific situation, they should provide you with a clear rationale for its use.

In summary, while some medications can be necessary during pregnancy, it is vital to approach this with caution. Always consult with your healthcare provider before making any decisions about medication use during pregnancy, especially with drugs classified as Category X. Your health and the health of your developing baby should always be the top priority, and your healthcare provider can help you navigate these decisions with the best available evidence and guidelines.

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