RU486: Risks of Pregnancy After Second Dose and Contraceptive Needs - Obstetrics and Gynecology

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RU486 second dose


After taking the second dose of RU486, I returned for a follow-up and confirmed that the embryo has been expelled, but there are still blood clots.
Therefore, I was prescribed two additional sublingual tablets.
The day after taking the sublingual tablets, I had unprotected intercourse.
Is there a risk of pregnancy? Do I need to take contraceptive pills?

Wenwen, 30~39 year old female. Ask Date: 2021/02/15

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, you probably do not need to take emergency contraception.
Wishing you good health.

Reply Date: 2021/02/15

More Info


RU486, also known as mifepristone, is a medication used for medical abortion. It works by blocking the hormone progesterone, which is necessary for the maintenance of pregnancy. After taking RU486, it is common for women to experience various side effects, including abdominal pain, cramping, and bleeding as the body expels the pregnancy.
In your case, since you have taken the second dose of RU486 and confirmed that the embryo has been expelled, it is important to understand the implications of engaging in unprotected intercourse shortly after this process.
Firstly, after taking RU486 and the subsequent medication (often misoprostol), the body undergoes significant hormonal changes. While the primary purpose of RU486 is to terminate a pregnancy, it does not provide any contraceptive protection. Therefore, if you engage in unprotected intercourse after the abortion process, there is a risk of becoming pregnant again.
The timing of ovulation is crucial here. After an abortion, a woman's menstrual cycle can take some time to return to normal. Ovulation can occur as early as two weeks after the abortion, which means that if you have unprotected sex during this time, there is a possibility of conception. If you are not planning to conceive again, it is advisable to use contraception immediately after the abortion.
Regarding the use of contraceptives, it is recommended to start a reliable form of birth control as soon as possible after the abortion. This could be hormonal contraceptives (like the pill, patch, or IUD) or barrier methods (like condoms). If you are considering hormonal contraceptives, consult with your healthcare provider about the best options for you, as they can help you choose a method that fits your health needs and lifestyle.

In summary, after taking RU486 and confirming the expulsion of the embryo, you should be aware that engaging in unprotected intercourse poses a risk of pregnancy. It is essential to consider starting a contraceptive method to prevent unintended pregnancies in the future. Always consult with your healthcare provider for personalized advice and to discuss the best contraceptive options for your situation.
Additionally, it is crucial to follow up with your healthcare provider after the abortion to ensure that the process is complete and to address any concerns you may have regarding your health and future pregnancies. Regular check-ups are important to monitor your recovery and to discuss any further reproductive health needs.

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Dr. Huang Jianzhong reply Obstetrics and Gynecology
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I would like to ask if having unprotected intercourse on the same day after taking the first dose of the medication will have any effects. Is there a possibility of becoming pregnant again?


Dr. Huang Zifei reply Obstetrics and Gynecology
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Hello, taking your medication on time will provide effective contraception. Wishing you good health.

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Hello, I would like to ask the doctor. I took RU486 on April 18, and two days later, on April 20, I took the second dose. On April 21 and April 25, I returned to the clinic, and the doctor prescribed uterotonics (three doses the day before the 24th and two doses the day before th...


Dr. Cao Guotao reply Obstetrics and Gynecology
Hello, the probability is low. A pregnancy test can only be accurate 12 days after intercourse, so you can only monitor the situation for now. Wishing you good health.

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