Side Effects of Ufur Capsules in Colorectal Cancer Treatment

Q: Side Effects of Ufur Capsules in Colorectal Cancer Treatment

Hello： 1. I cannot comment on traditional Chinese medicine as I am not familiar with it. 2. This is something you should discuss with the primary physician; I cannot answer on their behalf. 3. The answer is the same as above. Thank you.

The side effects of Ufur Rejuvenation Capsules?

Hello, doctor.
My mother is approximately 68 years old and was diagnosed with colon cancer during a health check last year.
She underwent surgery to remove the tumor in August, and the pathology report classified it as stage 2A.
She started taking Ufur capsules in September of last year and underwent two blood tests at the end of October and the end of January this year.
Both tests showed a decrease in red blood cells, white blood cells, and platelets (hovering around the lower limit of normal values).
These changes were noted in the educational materials, so my mother and we were somewhat prepared for this.
However, we are concerned that her liver function indices have also started to rise above normal ranges, and she has been experiencing fatigue and weakness in her limbs.
The values from the two tests were GOT 22->37, GPT 22->71, and bilirubin 1.2->1.8.
During her follow-up visit, the attending physician prescribed Sinomenine capsules and Lidanling tablets as a response treatment, and she continues to take Ufur.
I would like to ask: 1.
Is my mother's liver function abnormality considered serious? Is it appropriate for her to take nutritional supplements like Antrodia camphorata or traditional Chinese medicine for liver health? 2.
Due to persistent side effects causing discomfort, my mother is contemplating discontinuing her medication.
Although I have heard that switching to injections may have stronger side effects, could the intermittent nature and limited frequency of injections provide patients with rest and a sense of an endpoint, making it a viable alternative? 3.
If her overall health continues to deteriorate, can she still continue with this type of adjuvant chemotherapy? As a family member, how can I help ensure her well-being? Thank you sincerely for your patience in reading and responding!

Preyer, 30~39 year old female. Ask Date: 2021/02/16

Dr. Chen Yunfang reply Oncology

Hello: 1.
I cannot comment on traditional Chinese medicine as I am not familiar with it.
2.
This is something you should discuss with the primary physician; I cannot answer on their behalf.
3.
The answer is the same as above.
Thank you.

Reply Date: 2021/02/16

More Info

Dear concerned family member,
Thank you for reaching out with your questions regarding your mother's treatment with UFUR capsules following her colorectal cancer surgery. It’s understandable to be worried about the side effects and overall health of a loved one undergoing cancer treatment. Let’s address your concerns one by one.

1. Liver Function Abnormalities: The liver function tests (LFTs) you mentioned, specifically the elevations in GOT (AST) and GPT (ALT), indicate that there may be some liver stress or damage. While the values you provided (GOT rising from 22 to 37 and GPT from 22 to 71) are elevated, they are not extremely high. However, any elevation in liver enzymes should be monitored closely, especially in the context of ongoing chemotherapy. It’s crucial to discuss these results with her oncologist, who can determine if these changes are significant enough to warrant a change in treatment or further investigation. As for using supplements like cow mushroom (牛樟芝) or traditional Chinese medicine for liver support, it’s essential to consult with her healthcare provider before introducing any new supplements. Some herbal products can interact with chemotherapy drugs, potentially affecting their efficacy or increasing toxicity.

2. Managing Side Effects and Treatment Alternatives: It’s not uncommon for patients to experience side effects from chemotherapy, which can lead to feelings of fatigue and discomfort. If your mother is considering discontinuing UFUR due to these side effects, it’s important to have an open discussion with her oncologist about her experiences. They may suggest supportive care options to alleviate symptoms, such as medications for nausea or fatigue. Regarding switching to injectable chemotherapy, while it’s true that some injectable forms may have different side effect profiles, they can also be more intense. The idea of having a treatment with a defined end point can be psychologically beneficial for some patients. However, the decision to switch therapies should be made collaboratively with her medical team, considering her overall health, cancer stage, and personal preferences.

3. Continuing Treatment with Deteriorating Health: If your mother’s overall health continues to decline, it may be necessary to reassess the appropriateness of continuing her current treatment regimen. Oncologists often evaluate the benefits versus the burdens of treatment, especially in patients experiencing significant side effects. As a family member, you can help by advocating for her needs, ensuring she communicates her symptoms and concerns to her healthcare team, and supporting her in making informed decisions about her treatment options. It’s also important to discuss palliative care options, which focus on improving quality of life and managing symptoms, regardless of the stage of cancer.

In summary, it’s vital to maintain open communication with her healthcare providers about her liver function and side effects. They can provide tailored advice and adjustments to her treatment plan. Supporting her emotionally and ensuring she feels heard in her treatment journey is equally important.
Wishing you and your mother strength and clarity during this challenging time.

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