Does Doxacillin Antibiotic Affect Birth Control Pill Effectiveness? - Obstetrics and Gynecology

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The antibiotic dicloxacillin 250 mg/capsule BID may affect the efficacy of oral contraceptives?


Hello, doctor.
I have been taking the regular oral contraceptive pill for a year.
On February 17, I consulted a physician who prescribed me the antibiotic dicloxacillin 250 mg, which I started taking twice a day on February 17.
My menstrual period started on February 18, and I began taking the first oral contraceptive pill on February 21.
My period ended on February 22, and I stopped taking the antibiotic on February 25.
I had sexual intercourse on February 21 and 22.
Will this affect the effectiveness of the contraceptive? Thank you.

Miss Lin, 20~29 year old female. Ask Date: 2021/02/25

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
Wishing you good health.

Reply Date: 2021/02/25

More Info


When it comes to the interaction between antibiotics and birth control pills, it's essential to understand the specifics of the antibiotic in question. In your case, you are asking about Doxacillin, which is a type of penicillin antibiotic.
Generally, most antibiotics do not interfere with the effectiveness of hormonal contraceptives, including birth control pills. However, there are exceptions, and the most notable one is Rifampin, which is known to significantly reduce the effectiveness of hormonal contraceptives. Doxacillin, on the other hand, is not typically associated with this interaction.
In your situation, you began taking Doxacillin on February 17 and started your birth control pill on February 21, after your menstrual period. You had sexual intercourse on February 21 and 22, during which you were still taking Doxacillin. Since Doxacillin is not known to affect the efficacy of birth control pills, it is unlikely that your contraceptive protection was compromised during this time.

However, it is important to note that the effectiveness of birth control pills can be influenced by various factors, including missed doses, gastrointestinal disturbances (like vomiting or diarrhea), and certain medications. If you took your birth control pill consistently and correctly, the likelihood of reduced effectiveness due to Doxacillin is minimal.

For added peace of mind, if you are concerned about potential interactions or if you experience any unusual symptoms, it is advisable to consult with your healthcare provider. They can provide personalized advice based on your medical history and current medications.

In summary, Doxacillin is not known to interfere with the effectiveness of birth control pills. As long as you took your contraceptive as directed, you should be protected against unintended pregnancy. Always communicate with your healthcare provider about any medications you are taking and their potential interactions with your birth control method.

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