Pancreatic Shadows: When to Seek Further Medical Evaluation - Gastroenterology and Hepatology

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Pancreatic examination


At the end of January, I had a CT scan, and the doctor mentioned there was a shadow on my pancreas, advising me to return for follow-up in three months.
Later, I went to the Veterans General Hospital for an MRI and underwent related blood tests (about 10 items, including the CA 19-9 marker).
The MRI results were normal, and all blood tests were also normal.
However, I still feel anxious.
Should I consider further examinations? I have been experiencing gastroesophageal reflux for a year, often feeling fatigued, having a poor appetite, and losing over 10 kilograms.
I also have shoulder and neck pain, insomnia, and recently, unexplained pain in my sternum (it hurts when pressed).
I am unsure if this is related to gastroesophageal reflux, autonomic nervous system dysfunction, psychological stress, or the pancreas.
Thank you very much for your response, doctor.
I appreciate it.

A-Wen, 40~49 year old female. Ask Date: 2021/03/08

Dr. Chen Shidian reply Gastroenterology and Hepatology


→ Discuss the follow-up plan with the attending physician regarding the results.

Reply Date: 2021/03/08

More Info


When it comes to pancreatic shadows or lesions observed in imaging studies, such as CT scans or MRIs, it is essential to approach the situation with a comprehensive understanding of the potential implications and the necessary follow-up actions. In your case, the initial CT scan indicated a shadow on the pancreas, which prompted further imaging and blood tests. The subsequent MRI results were normal, and your blood tests, including the CA 19-9 marker, returned within normal limits. However, you are still experiencing various symptoms, including gastroesophageal reflux, fatigue, weight loss, and chest pain, which understandably raises concerns.

Firstly, it is important to recognize that not all pancreatic shadows are indicative of cancer. They can represent a variety of conditions, including benign cysts, pseudocysts (often related to pancreatitis), or even normal anatomical variations. The fact that your MRI was normal and your blood tests did not show elevated tumor markers is reassuring. Elevated CA 19-9 levels can be associated with pancreatic cancer, but they can also be elevated in other conditions, including pancreatitis and even benign diseases. Therefore, a normal CA 19-9 level does not rule out pancreatic issues entirely but does reduce the likelihood of malignancy.

Given your symptoms, it is crucial to consider the broader context of your health. Gastroesophageal reflux disease (GERD) can cause significant discomfort and may lead to symptoms such as chest pain, which can sometimes be mistaken for cardiac issues. The fatigue and weight loss you are experiencing could be related to a variety of factors, including dietary changes due to your reflux, stress, or other underlying health conditions. The shoulder and neck pain, along with insomnia, could also be manifestations of stress or anxiety, which can exacerbate physical symptoms.

In terms of follow-up, the recommendation to wait three months for a repeat imaging study is standard practice in many cases, especially when initial tests do not indicate a high risk of malignancy. However, if your symptoms persist or worsen, it is essential to communicate this to your healthcare provider. They may consider additional evaluations, such as an endoscopic ultrasound (EUS), which can provide more detailed imaging of the pancreas and surrounding structures, or even a biopsy if there is a persistent concern.

Moreover, it is crucial to address your symptoms holistically. If you are experiencing significant anxiety or stress related to your health concerns, it may be beneficial to speak with a mental health professional. Stress management techniques, such as mindfulness, cognitive behavioral therapy, or relaxation exercises, can be helpful in managing both psychological and physical symptoms.

In conclusion, while the initial findings of a pancreatic shadow warrant careful monitoring, the normal MRI and blood tests are encouraging. It is essential to maintain open communication with your healthcare provider about your ongoing symptoms and concerns. If your symptoms do not improve or if you have new or worsening symptoms, do not hesitate to seek further evaluation. Your health and peace of mind are paramount, and proactive management is key to addressing both physical and emotional well-being.

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