Post-Cold Cough: Is It Related to Lung Nodules? - Pulmonology

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Coughing after a cold?


Hello, Doctor! My wife caught a cold during the Lunar New Year this year, and the doctor diagnosed it as a cold leading to sinusitis, prescribing antibiotics.
During the course of treatment, her cold symptoms improved, but she then developed a mild cough.
So far, we have visited three clinics.

The first clinic diagnosed her with a cold due to yellow nasal discharge and prescribed antibiotics for 5 days.
Upon follow-up, the doctor noted some side effects from the antibiotics and determined that the inflammation had significantly decreased, recommending to stop the medication.

The second clinic, an ENT specialty, was consulted after she developed a mild cough following the cessation of antibiotics.
The doctor assessed that there was still inflammation in both the sinuses and throat, suggesting to continue with antibiotics for another 10 days.
During this period, her cough improved but did not completely resolve.

In the third clinic, which we visited this week, the doctor concluded that the throat inflammation had healed, but there was still mild inflammation in the sinuses, so a different antibiotic was prescribed.
Currently, she rarely coughs, only experiencing a tickling sensation in her throat when eating or exposed to cold air, prompting a cough.
A year ago, my wife was diagnosed with early-stage lung adenocarcinoma (0.8 cm, subpleural type), which was surgically removed, and she has been returning for check-ups every six months.
During her last follow-up before the Lunar New Year, a new ground-glass opacity (0.7 cm pulmonary nodule) was found in the left upper lung.
The attending physician, after reviewing the CT scan, initially assessed it as an inflammatory process since the previous examination six months prior was normal, and this was a sudden finding.
A follow-up in three months was recommended, and her next appointment is scheduled for mid-April.
I would like to ask whether the current cough is primarily due to the cold or if it could be related to the 0.7 mm pulmonary nodule.
Is it possible for the nodule to grow in a short period and cause coughing? I would greatly appreciate your advice and response.
Thank you!

Xinji de zhangfu, 40~49 year old female. Ask Date: 2021/03/18

Dr. Huang Yiwen reply Pulmonology


Dear Anxious Husband: If there was a 0.8 cm early-stage lung adenocarcinoma a year ago, the 0.7 cm ground-glass nodule should not be taken lightly.
It is best to return to the original surgeon for a detailed examination of the small lung nodule, as it may not cause a chronic cough.
This is also one of the reasons early-stage lung cancer is difficult to diagnose.
Your wife's cough, upon analysis, should be attributed to an allergic reaction.
Changhua Hospital is concerned about you.

Reply Date: 2021/03/18

More Info


Understanding the relationship between post-cold cough and lung nodules, especially in the context of a history of lung adenocarcinoma, is crucial for both patients and healthcare providers. Your inquiry highlights a common concern among patients who have experienced respiratory infections and have a history of lung nodules or cancer.

Firstly, it is important to recognize that cough following a respiratory infection, such as a cold or sinusitis, is a frequent occurrence. This cough can persist even after the acute symptoms have resolved. In your case, the cough seems to have developed after a cold that led to sinusitis, which is characterized by inflammation of the sinus cavities. This inflammation can lead to post-nasal drip, where mucus drips down the back of the throat, causing irritation and a cough reflex. This is a common symptom associated with sinusitis and can explain the cough you are experiencing, particularly when eating or exposed to cold air.

Regarding the lung nodules, specifically the newly identified ground-glass nodule (GGN) in the left upper lung measuring 0.7 cm, it is essential to understand the nature of these nodules. Ground-glass opacities can represent a range of conditions, from benign processes such as inflammation or infection to more concerning entities like atypical adenomatous hyperplasia or even early-stage lung cancer. The fact that this nodule was not present in previous imaging suggests that it is a new finding, which warrants careful monitoring.

Your concern about whether the cough could be related to the lung nodule is valid. While it is possible for lung nodules to cause cough, especially if they are large or located in a way that irritates surrounding tissues, a small ground-glass nodule like the one you described is less likely to be the direct cause of a cough. Instead, the cough is more likely a residual effect of the recent respiratory infection and sinusitis. However, it is important to remain vigilant, as any new or persistent cough in a patient with a history of lung cancer should be evaluated thoroughly.

In terms of the growth of lung nodules, it is important to note that while some nodules can grow rapidly, many remain stable over time. The recommendation for follow-up imaging in three months is appropriate, as it will help determine whether the nodule is stable or shows signs of growth, which could indicate a need for further investigation.

In summary, the cough you are experiencing is most likely related to the recent cold and sinusitis rather than the lung nodule. However, due to your medical history, it is crucial to follow up with your healthcare provider as scheduled. They will be able to assess the nodule's characteristics and any changes in your symptoms. Regular monitoring and communication with your healthcare team are key components in managing your health, especially in the context of previous lung cancer. If your cough worsens or if you experience new symptoms, such as shortness of breath or chest pain, it is important to seek medical attention promptly.

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