Can You Take A Acid and Uriel Together? Side Effects Explained - Psychiatry

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The side effects of medication A (Isotretinoin)?


Hello, doctor.

1.
I have been taking an antidepressant (Ulipristal 10mg) for about 3 days, but I have also been taking oral isotretinoin.
Can these two medications be taken together? I take isotretinoin with breakfast and take Ulipristal before bed.

2.
Does Ulipristal have side effects such as weight gain and constipation?

Shu, 20~29 year old female. Ask Date: 2021/03/26

Dr. Peng Liyun reply Psychiatry


Hello! Here are the answers to your questions: 1.
Oral isotretinoin and fluoxetine do not have any drug interactions and can be used simultaneously.
2.
The more common gastrointestinal side effects of fluoxetine include decreased appetite, nausea, and constipation; however, it may potentially increase appetite as it improves symptoms of depression.
Best wishes, Peng Li-Yun, Department of Child and Adolescent Psychiatry, Shun-Hsin Chia-Nan Psychiatric Hospital.

Reply Date: 2021/03/26

More Info


When considering the concurrent use of oral isotretinoin (commonly referred to as A Acid) and the antidepressant Uriel (which contains the active ingredient fluoxetine), it's essential to understand the potential interactions and side effects associated with these medications.

1. Drug Interaction: Based on current medical knowledge, there are no significant drug interactions reported between isotretinoin and fluoxetine. This means that taking these two medications together is generally considered safe. However, it is crucial to monitor for any unusual side effects or changes in your health status, as individual responses to medications can vary. Always consult your healthcare provider before starting or combining medications, especially if you have underlying health conditions or are taking other medications.

2. Side Effects of Isotretinoin: Isotretinoin is a powerful medication primarily used to treat severe acne. Common side effects include dry skin, chapped lips, and increased sensitivity to sunlight. More serious side effects can include mood changes, liver function alterations, and potential effects on lipid levels. Patients are often advised to have regular follow-ups to monitor these parameters, especially liver enzymes and lipid profiles.

3. Side Effects of Uriel (Fluoxetine): Fluoxetine, an SSRI (selective serotonin reuptake inhibitor), is commonly prescribed for depression and anxiety disorders. While it can be effective in managing these conditions, it does come with potential side effects. Some of the common side effects include nausea, insomnia, fatigue, and sexual dysfunction. Regarding your specific concerns, fluoxetine can lead to weight gain in some individuals, though this is not universal. It is also known to cause gastrointestinal disturbances, which could manifest as constipation in some patients.

4. Managing Side Effects: If you are experiencing side effects from either medication, it is important to communicate these with your healthcare provider. They may suggest lifestyle modifications, dietary changes, or even adjustments to your medication regimen to help mitigate these effects. For instance, if constipation becomes an issue with fluoxetine, increasing fiber intake, staying hydrated, and regular physical activity can be beneficial.

5. Monitoring and Follow-Up: Since you are taking both isotretinoin and fluoxetine, regular follow-ups with your healthcare provider are essential. They can help monitor your mental health status, skin condition, and any side effects you may experience. This is particularly important because isotretinoin can sometimes exacerbate mood changes, and fluoxetine may take several weeks to show its full effect.

In summary, taking isotretinoin and fluoxetine together is generally safe, but it is crucial to be vigilant about monitoring for side effects. If you have any concerns or experience any adverse effects, do not hesitate to reach out to your healthcare provider for guidance. They can provide personalized advice based on your health history and current treatment plan.

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