Interstitial Cystitis and Urinary Tract Infections: Your Questions Answered - Urology

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Urinary tract infection (UTI)


Hello, doctor.
I have been diagnosed with interstitial cystitis for a year.
During this year, I have undergone two rounds of hyaluronic acid treatment, and my condition has been manageable.
However, after a round of medication in the second half of the year, I started experiencing urinary frequency, and I am now applying for a third round.
I went to another hospital where Dr.
A conducted a urinalysis, and the results showed bacteria but no white blood cells, so he advised against taking antibiotics.
The next day, at the hospital where I am applying for the hyaluronic acid treatment, a bacterial culture showed growth, and Dr.
B identified it as Corynebacterium.
Dr.
B recommended that I take antibiotics.
I would like to ask if the presence of bacteria in the culture, despite the low white blood cell count, indicates an infection.
Should I take antibiotics? Can drinking more water help flush out the bacteria? Currently, I do not have urinary frequency, but I still experience bladder pain from interstitial cystitis.
After my last course of antibiotics, I developed a vaginal infection that took six months to resolve, so I am apprehensive.
I want to confirm this.
Thank you, doctor!

Xiao Hua, 50~59 year old female. Ask Date: 2021/03/30

Dr. Du Shixi reply Urology


Hello: 1) Is there an infection? This may relate to your urine sample collection.
Was it done aseptically? For females, if urine is collected improperly, it can lead to contamination.
Please refer to the following guidelines from National Taiwan University Hospital: https://www.ntuh.gov.tw/labmed/Fpage.action?muid=4707&fid=51323.3.2.
Female patients should use a sterile tissue (or a clean tissue if sterile ones are unavailable) to wipe the genital area from the urethral opening downwards to ensure cleanliness and to prevent pubic hair from contaminating the urine sample.
The first portion of urine should be voided into the toilet or urinal, and the second portion should be collected in the specimen container, with any remaining urine voided into the toilet or urinal.
2) If there is a urinary tract infection, it should be assessed based on symptoms and test results.
If there are no symptoms but the urinalysis shows abnormalities, it may indicate a poor sample.
If symptoms are present but the tests are normal, some physicians may worry that it is an early infection that is difficult to detect and may prescribe antibiotics.
Regarding the vaginal infection that occurred four days after taking antibiotics, due to the female anatomy, both conditions can coexist.
Wishing you good health; I personally recommend redoing the urinalysis.

Reply Date: 2021/03/30

More Info


Interstitial cystitis (IC) is a chronic condition characterized by bladder pressure, bladder pain, and sometimes pelvic pain. It can lead to frequent urination and urgency, which can significantly impact the quality of life. Your situation, having been diagnosed with IC for a year and undergoing treatments such as hyaluronic acid instillations, indicates that you are actively managing your condition. However, the recent development of urinary tract infection (UTI) symptoms, particularly with the presence of bacteria in your urine, raises important questions regarding treatment and management.

When it comes to the presence of bacteria in urine without a significant number of white blood cells (WBCs), it can be somewhat confusing. Typically, a UTI is diagnosed when there are both bacteria and WBCs present in the urine. The WBCs indicate an inflammatory response, suggesting that the body is fighting an infection. However, in some cases, bacteria can be present without a corresponding increase in WBCs, which may indicate a less aggressive infection or a colonization rather than a full-blown infection.

In your case, the presence of "仙人掌菌" (likely referring to a type of bacteria that may not be commonly pathogenic) might not necessitate antibiotic treatment if you are asymptomatic. However, the recommendation from the doctor to take antibiotics suggests that they believe the bacteria could still be contributing to your symptoms or could lead to complications if left untreated. It is essential to weigh the risks and benefits of antibiotic therapy, especially considering your history of antibiotic-associated vaginal infections.

Drinking plenty of water can indeed help flush out bacteria from the urinary tract, but it may not be a definitive solution if an infection is present. Increased hydration can dilute urine and promote urination, which may help in clearing out bacteria. However, if the bacteria are causing inflammation or if they are resistant to being flushed out, antibiotics may still be necessary.

Given your history of developing a vaginal infection after antibiotic use, it is understandable that you are hesitant to start another course of antibiotics. Here are some considerations:
1. Consultation with a Specialist: It may be beneficial to consult a urologist or a specialist in IC who can provide tailored advice based on your specific situation. They can help determine if the bacteria present is clinically significant and whether antibiotics are warranted.

2. Monitoring Symptoms: Keep a close eye on your symptoms. If you start experiencing increased bladder pain, urgency, or frequency, it may indicate that the bacteria are indeed causing an infection that requires treatment.

3. Alternative Therapies: Discuss with your healthcare provider about alternative therapies that may help manage both IC and any potential UTI symptoms. This could include medications that help with bladder pain or other non-antibiotic treatments.

4. Probiotics: If you do need to take antibiotics, consider discussing the use of probiotics with your healthcare provider. Probiotics can help restore the natural flora of the vagina and urinary tract, potentially reducing the risk of developing a yeast infection after antibiotic treatment.

5. Hydration and Diet: Continue to stay well-hydrated and consider dietary adjustments that may help with IC symptoms, such as avoiding irritants like caffeine, alcohol, and spicy foods.

In conclusion, while the presence of bacteria without significant WBCs may not always indicate a UTI, it is crucial to consider your symptoms and medical history when deciding on treatment. Open communication with your healthcare provider is key to finding the best approach for your situation.

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