Persistent Swelling After Hornet Stings: Allergic Reactions Explained - Surgery

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Mosquito bites (Asian giant hornet stings)


Last July, I was stung by a hornet on my calf.
After applying medication and icing the area, the swelling subsided.
However, even now, the sting site occasionally swells up.
It resolves after applying medication or sometimes even without treatment.
Over the past nine months, this swelling has occurred about 3 to 5 times.
I would like to know if this is an allergic reaction at the sting site or if it is related to the toxin not being fully metabolized.
Thank you.

Xiao Ai, 40~49 year old female. Ask Date: 2021/04/06

Dr. Li Zhonghuai reply Surgery


Hello! It is recommended to visit a general surgery outpatient clinic to check for any remaining bee stingers.
Take care! Changhua Hospital cares about you!

Reply Date: 2021/04/06

More Info


Persistent swelling after a hornet sting can be a concerning symptom, especially if it recurs several months after the initial incident. In your case, the swelling that occurs intermittently at the site of the sting could be attributed to a few different factors, primarily related to allergic reactions and the body's response to the venom.

When a hornet stings, it injects venom that contains various proteins and enzymes. These substances can trigger an immune response, leading to localized swelling, redness, and pain. In most cases, this reaction is temporary and resolves within a few hours to a few days. However, some individuals may experience prolonged or recurrent swelling due to a condition known as "delayed hypersensitivity." This is a type of allergic reaction that can occur days or even weeks after the initial exposure to the allergen—in this case, the hornet venom.

The fact that you have experienced swelling at the sting site multiple times over the past nine months suggests that your body may still be reacting to the venom. This could be due to residual inflammation or sensitivity at the site of the sting. It is also possible that the initial sting has led to a localized allergic reaction that can be triggered by various factors, such as changes in temperature, physical activity, or even stress.

In some cases, the swelling could be a result of a secondary infection, especially if the area was scratched or irritated after the sting. Signs of infection include increased redness, warmth, pus, or fever. If you notice any of these symptoms, it is essential to seek medical attention.

As for the concern about the venom not being metabolized, it is important to note that the body typically breaks down and eliminates the components of the venom over time. However, the immune system's memory of the venom can persist, leading to recurrent symptoms. This is similar to how some individuals may develop allergies to certain foods or insect stings after initial exposure.

To manage the swelling, you can continue to apply topical treatments, such as hydrocortisone cream or antihistamines, which can help reduce inflammation and itching. Ice packs can also be beneficial in alleviating swelling and discomfort. If the swelling persists or worsens, or if you experience other symptoms such as difficulty breathing, hives, or widespread swelling, it is crucial to seek medical evaluation. An allergist or immunologist can perform tests to determine if you have developed an allergy to hornet venom and discuss potential treatment options, including allergy desensitization therapy if necessary.

In summary, the intermittent swelling at the site of your hornet sting is likely related to an allergic reaction or delayed hypersensitivity to the venom. While the body generally metabolizes the venom over time, the immune response can continue to trigger symptoms. Monitoring the area for signs of infection and consulting with a healthcare professional if symptoms persist is advisable.

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