Concerns About Long-Term Use of Topical Steroids for Lip Eczema - Dermatology

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Lip medication consultation questions?


Hello, Doctor: I apologize for the interruption.
I have been experiencing allergic eczema issues on my lips, particularly at the corners.
The doctor prescribed Gentasone ointment for me to apply on my lips.
Although my symptoms improve after application, they tend to recur after a while, leading me to return for follow-ups.
I have been using this intermittently for two years.
The prescription mentioned that a side effect of the medication is skin thinning, but I am concerned because I have heard that prolonged use of steroid medications can lead to conditions such as glaucoma.
Given my situation, is my risk of developing glaucoma significantly high?

Haipa de ren, 20~29 year old female. Ask Date: 2021/04/11

Dr. Wu Yuxin reply Dermatology


It won't be applied to the lips.

Reply Date: 2021/04/11

More Info


Long-term use of topical steroids, such as Gentasone, for conditions like lip eczema can indeed raise concerns regarding potential side effects, including skin thinning and other systemic effects. Your experience of recurrent symptoms after discontinuing the medication is common in chronic skin conditions, where the underlying cause may not be fully addressed by topical treatments alone.

Topical corticosteroids are effective in reducing inflammation and controlling symptoms of eczema, but their long-term use can lead to several side effects. The primary concern with prolonged use is skin atrophy, which is the thinning of the skin. This can make the skin more susceptible to bruising, tearing, and other injuries. Additionally, the skin barrier function may be compromised, leading to increased sensitivity and potential for further irritation.

Regarding your concern about glaucoma, it is important to note that the risk of developing glaucoma from topical steroids is generally associated with the use of potent steroids, especially when applied to sensitive areas or used over large surface areas for extended periods. The eyes are particularly sensitive to steroids, and while the risk of developing glaucoma from topical application to the lips is significantly lower than from systemic steroid use or ocular steroids, it is not entirely negligible. The risk increases with the potency of the steroid, the duration of use, and individual susceptibility.

In your case, using Gentasone on the lips for two years may not pose a high risk for glaucoma, but it is essential to monitor for any signs of increased intraocular pressure, especially if you have a family history of glaucoma or other risk factors. Regular eye examinations can help detect any changes early.

To manage your lip eczema effectively while minimizing the risks associated with long-term steroid use, consider the following strategies:
1. Use the Lowest Potency Necessary: If possible, discuss with your doctor the option of using a lower-potency steroid or a non-steroidal topical treatment. Non-steroidal options, such as calcineurin inhibitors (e.g., tacrolimus), may be effective for sensitive areas like the lips without the same risk of skin thinning.

2. Moisturization: Regularly apply emollients or moisturizers to the lips to maintain hydration and support the skin barrier. This can help reduce the frequency of flare-ups and the need for steroid use.

3. Identify Triggers: Work with your healthcare provider to identify and avoid potential triggers for your eczema, such as certain foods, allergens, or irritants.

4. Regular Follow-Up: Schedule regular follow-ups with your dermatologist to monitor your condition and adjust your treatment plan as necessary. This can help prevent the need for prolonged steroid use.

5. Consider Alternative Therapies: If your eczema is persistent and does not respond to topical treatments, your doctor may recommend other therapies, such as phototherapy or systemic medications.

In conclusion, while long-term use of topical steroids like Gentasone can lead to side effects, the risk of developing glaucoma from such localized use is relatively low. However, it is crucial to remain vigilant and maintain open communication with your healthcare provider about your treatment plan and any concerns you may have. Regular monitoring and a comprehensive approach to managing your eczema can help mitigate risks and improve your overall skin health.

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