Do Birth Control Pills Interact with Antidepressants? - Pharmacology

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I would like to ask if there are any interactions between the contraceptive pill and antidepressant medications?


Hello Doctor: Will the ingredients in Gveza 3mg/0.02mg Film Coated Tablets (DROSPIRENONE, Ethinyl estradiol) interact with the following medications: Lorazepam (LORAZIN) and Leeyo? Thank you!

Ning, 20~29 year old female. Ask Date: 2021/04/16

Dr. Chen Yuemei reply Pharmacology


Hello: Upon review, the medication Gveza (active ingredients: Drosperinone, Ethinyl Estradiol) may increase the hepatic metabolism of Lorazepam (LORAZIN), thereby reducing the effectiveness of Lorazepam.
When taking these medications together, you should monitor the therapeutic effects of Lorazepam.
If you find that the treatment is not effective, please consult your prescribing physician to adjust your medication.
Wishing you all the best.

Reply Date: 2021/04/16

More Info


When considering the interaction between birth control pills and antidepressants, it's essential to understand how these medications work and their potential effects on each other. Birth control pills, such as those containing drospirenone and ethinyl estradiol, are hormonal contraceptives that primarily function by preventing ovulation, altering the uterine lining, and thickening cervical mucus to prevent sperm from reaching an egg. On the other hand, antidepressants like lorazepam (often used for anxiety and depression) and other medications can affect neurotransmitter levels in the brain.

Research indicates that hormonal contraceptives can influence the metabolism of certain antidepressants, potentially altering their effectiveness. For example, some studies suggest that estrogen can affect the metabolism of drugs processed by the liver, which may lead to either increased or decreased levels of the antidepressant in the bloodstream. This interaction can vary depending on the specific antidepressant and the individual's metabolic response.

Lorazepam, which is a benzodiazepine, is not typically known to have significant interactions with hormonal contraceptives. However, it's crucial to monitor for any changes in mood or anxiety levels when starting or stopping any medication, including birth control pills. If you notice any changes in your mental health or the effectiveness of your antidepressant, it's essential to discuss these with your healthcare provider.

Leeyo (likely referring to a specific antidepressant) may have different interactions depending on its pharmacological profile. Some antidepressants, particularly those that are metabolized by the liver, may have their effectiveness altered by the hormonal components of birth control pills. Therefore, it is advisable to consult with your physician or pharmacist regarding the specific interactions between your birth control and any antidepressants you are taking.

In summary, while there may not be a direct interaction between drospirenone/ethinyl estradiol and lorazepam, the potential for hormonal contraceptives to influence the metabolism of certain antidepressants warrants careful monitoring. Always consult with your healthcare provider to ensure that your treatment plan is safe and effective, and to address any concerns regarding medication interactions. They can provide personalized advice based on your medical history and current medications, ensuring that both your contraceptive and mental health needs are adequately managed.

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