Is Cold Weather a Cause of Amyotrophic Lateral Sclerosis? - Neurology

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Cold-induced amyotrophic lateral sclerosis (ALS)


Hello doctor, I recently came across this article https://k.sina.cn/article_6436228314_17fa10cda00100rlt8.html?from=health and would like to ask if the common cold is one of the causes of amyotrophic lateral sclerosis (ALS)? Thank you, doctor.

Mr. Huang, 20~29 year old female. Ask Date: 2021/04/26

Dr. Hong Weibin reply Neurology


Hello: According to a discussion on risk factors for amyotrophic lateral sclerosis (ALS) published in the Clinical Epidemiology journal in 2015, certain viral infections may be potential risk factors for ALS, including human herpesvirus HHV-6, HHV-8, human T-lymphotropic virus HTLV-1, and human endogenous retrovirus HERV-K, among others.
Currently, there is no evidence to suggest that cold viruses are risk factors for ALS.
Reference: Ingre C, Roos PM, Piehl F, Kamel F, Fang F.
Risk factors for amyotrophic lateral sclerosis.
Clin Epidemiol.
2015;7:181-193.
Published 2015 Feb 12.
doi:10.2147/CLEP.S37505.

Reply Date: 2021/04/26

More Info


Cold weather has been a topic of interest in relation to various health conditions, including neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS), commonly known as Lou Gehrig's disease. However, it is essential to clarify that while environmental factors, including temperature, can influence the onset and progression of certain diseases, there is currently no direct evidence linking cold weather as a cause of ALS.

ALS is a progressive neurodegenerative disease that affects motor neurons in the brain and spinal cord, leading to muscle weakness, disability, and eventually respiratory failure. The exact cause of ALS remains largely unknown, although it is believed to result from a combination of genetic and environmental factors. Research has identified several potential risk factors, including age, gender (more common in men), family history, and possibly exposure to certain toxins or heavy metals. However, cold weather or common colds (viral infections) have not been established as direct causes of ALS.

The article you referenced may discuss the broader implications of environmental factors on neurological health, but it is crucial to differentiate between correlation and causation. While some studies suggest that extreme temperatures may exacerbate symptoms in individuals with existing neurological conditions, this does not imply that cold weather directly causes ALS. Instead, it may influence the overall health and well-being of individuals who are already at risk or suffering from neurological disorders.

Moreover, viral infections, including those that cause the common cold, have been studied in relation to various neurological conditions. Some research indicates that viral infections can trigger immune responses that may contribute to neurodegenerative processes. However, this is a complex area of study, and more research is needed to understand the potential links between viral infections and ALS fully.

In summary, while cold weather and viral infections can impact health, there is no conclusive evidence to suggest that they are direct causes of ALS. If you or someone you know is concerned about ALS or related symptoms, it is essential to consult a healthcare professional for a thorough evaluation and appropriate management. Early diagnosis and intervention can significantly impact the quality of life for individuals with ALS and other neurodegenerative diseases.
In conclusion, while environmental factors, including temperature, can influence health, they are not definitive causes of ALS. Ongoing research continues to explore the complex interplay between genetics, environment, and neurodegenerative diseases, and it is vital to rely on scientific evidence when considering the causes of such conditions.

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