Should Men Get the HPV Vaccine? Key Questions Answered - Urology

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Should the HPV vaccine be administered?


Hello Doctor: I recently saw news mentioning that the HPV vaccine is not only recommended for girls but also suggested for boys.
Therefore, I am considering getting the 9-valent vaccine, but the out-of-pocket cost is expensive! I would like to ask the following questions: 1.
Is it really necessary for males to receive the HPV vaccine? 2.
Are there any risks associated with receiving the HPV vaccine? 3.
How does the vaccine provide protection? Is it through introducing the HPV virus into the body to stimulate an immune response? If so, what kind of reactions can the body have after vaccination? I look forward to your response.
Thank you!

Mr. Chen, 30~39 year old female. Ask Date: 2021/04/27

Dr. Du Shixi reply Urology


Hello: The content is quite extensive, so please refer to the package insert for reference.
1.
https://info.fda.gov.tw/mlms/H0001D.aspx?Type=Lic&LicId=60001001 Check the indications section; this vaccine has been approved by the government for specific populations.
2.
https://info.fda.gov.tw/mlms/H0001D3.aspx?LicId=60001001 Download the approved package insert, particularly pages 7-8, especially section 6.2 regarding post-marketing experience.
Of course, if you have the patience, you can start from the beginning.
3.
GARDASIL 9 is a non-infectious recombinant 9-valent vaccine for human papillomavirus (HPV).
This vaccine is prepared by purifying virus-like particles (VLPs) formed from the major capsid protein (L1) of HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58.
It is not derived from the virus directly; if it were, it would cause infection rather than immunity.
Wishing you good health.

Reply Date: 2021/04/27

More Info


The question of whether men should receive the HPV vaccine is increasingly relevant, especially as awareness of HPV-related health risks grows. Here, I will address your questions regarding the necessity, risks, and mechanisms of the HPV vaccine for men.

1. Do men really need to get the HPV vaccine?
Yes, men should consider getting the HPV vaccine. While HPV is often associated with cervical cancer in women, it can also lead to several types of cancers in men, including anal, penile, and oropharyngeal cancers. The Centers for Disease Control and Prevention (CDC) recommends the HPV vaccine for males aged 9 to 26 years, and it can be beneficial for older males as well, particularly those who may be at higher risk due to multiple sexual partners or those who are immunocompromised. Vaccination can help reduce the risk of HPV-related diseases and can also contribute to herd immunity, protecting those who may not be vaccinated.

2. What are the risks associated with receiving the HPV vaccine?
The HPV vaccine is generally considered safe, with most side effects being mild and temporary. Common side effects include pain at the injection site, fever, dizziness, and nausea. Serious side effects are rare. It is important to discuss any personal health concerns with a healthcare provider before vaccination. They can provide guidance based on individual health history and potential allergies.

3. How does the vaccine provide protection?
The HPV vaccine works by stimulating the immune system to produce antibodies against specific strains of the virus. The Gardasil 9 vaccine, for instance, protects against nine HPV types, including those most commonly associated with cancer and genital warts (types 6, 11, 16, 18, 31, 33, 45, 52, and 58). Importantly, the vaccine does not contain live virus; instead, it uses virus-like particles (VLPs) that mimic the structure of the virus but cannot cause infection. This means that after vaccination, the body recognizes these particles as foreign and mounts an immune response, creating memory cells that will respond if exposed to the actual virus in the future.

After receiving the vaccine, some individuals may experience mild reactions such as soreness at the injection site or low-grade fever. These reactions are normal and indicate that the immune system is responding to the vaccine.

In summary, men should consider getting the HPV vaccine as it can significantly reduce the risk of various HPV-related cancers and diseases. The vaccine is safe, with minimal risks, and works by training the immune system to recognize and combat the virus. If you have concerns about the cost or specific health conditions, discussing these with a healthcare provider can help clarify the benefits and address any financial concerns. Vaccination is an important step in promoting overall health and preventing HPV-related complications.

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