Do Antibiotics Affect the Effectiveness of Birth Control Pills? - Obstetrics and Gynecology

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Interaction between emergency contraceptive pills and antibiotics (specifically penicillin)?


Hello Doctor: I usually take "Yueji" for preemptive contraception.
This month, due to a urinary tract infection, I went to the gynecology department and was prescribed Cephalexin for a week.
However, I read online that taking antibiotics can reduce the effectiveness of contraceptive pills.
I'm wondering if taking this medication will affect the effectiveness of "Yueji." Thank you for your response!

Ms. Li, 20~29 year old female. Ask Date: 2021/04/27

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
Wishing you good health.

Reply Date: 2021/04/27

More Info


The concern regarding the interaction between antibiotics and birth control pills is a common one among patients. Specifically, you mentioned taking Cephalexin, a type of antibiotic, while regularly using a birth control pill for contraception. Let’s delve into this topic to clarify the potential effects of antibiotics on the effectiveness of birth control pills.

First and foremost, it is essential to understand that not all antibiotics have the same impact on hormonal contraceptives. The most commonly cited antibiotic that may reduce the effectiveness of birth control pills is Rifampin, which is used to treat tuberculosis and some other infections. Rifampin can induce liver enzymes that metabolize hormones, thereby potentially lowering the levels of contraceptive hormones in the bloodstream. However, most other antibiotics, including Cephalexin, do not have this effect.

Cephalexin is a cephalosporin antibiotic that is typically used to treat bacterial infections, including urinary tract infections (UTIs). Research and clinical guidelines indicate that Cephalexin does not significantly affect the efficacy of birth control pills. The consensus among healthcare professionals is that the use of most antibiotics, including Cephalexin, should not compromise the effectiveness of hormonal contraceptives.

That said, there are a few important considerations to keep in mind. While Cephalexin itself is not known to interfere with birth control pills, any medication that causes gastrointestinal disturbances—such as vomiting or diarrhea—could potentially affect the absorption of the contraceptive pill. If a woman experiences severe gastrointestinal symptoms that lead to missed doses or improper absorption of the pill, this could theoretically reduce its effectiveness.

Additionally, it is crucial to maintain consistent use of your birth control method. If you are taking antibiotics and are concerned about potential interactions, it may be wise to use a backup method of contraception, such as condoms, during the course of your antibiotic treatment and for a short period afterward, just to be safe. This is particularly important if you experience any side effects from the antibiotic that could affect your ability to take your birth control pill as scheduled.

In conclusion, taking Cephalexin should not affect the effectiveness of your birth control pills. However, if you have any lingering concerns or experience unusual symptoms, it is always best to consult with your healthcare provider for personalized advice. They can provide guidance tailored to your specific situation and help ensure that you are adequately protected against unintended pregnancy while managing your urinary tract infection. Remember, open communication with your healthcare provider is key to navigating any health concerns effectively.

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Hello, it generally does not have an impact. Wishing you good health.

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