Is a Cholesterol Level of 254 mg/dL Dangerous? Doctor's Advice - Gastroenterology and Hepatology

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Cholesterol level of 254, no need for medication?


Hello, Dr.
Chang.
I have had hepatitis B since I was about 12 years old.
Recently, while I was abroad, I experienced some discomfort, such as slight swelling and pain on the left side of my neck and muscle discomfort in my left shoulder, which led me to seek medical attention.
I also requested a blood test.
The results showed S_AST at 0.64 ukat/L, S_ALT at 0.98 ukat/L, and cholesterol at 6.58 mmol/L, which converts to 254 mg/dL in Taiwan, indicating that it is considered very high.
Additionally, the blood report did not specify triglycerides or high-density lipoprotein (HDL) levels (I did not see terms like LDL or HDL).
The doctor here mentioned that I appear thin (I am approximately 157 cm tall and weigh around 54-55 kg, but many of my friends in Taiwan say I look like I weigh in the 40s kg range.
People here generally have more body mass), so it is not very serious, and they did not prescribe any medication for lowering cholesterol or related to hepatitis.
Should I really not take any medication?

Miss Wang, 40~49 year old female. Ask Date: 2021/05/10

Dr. Zhang Kebin reply Gastroenterology and Hepatology


Dear Ms.
Wang,
You have had hepatitis B since the age of 12.
Recently, while abroad, you experienced discomfort, such as mild swelling and pain on the left side of your neck and muscle discomfort in your left shoulder, prompting you to seek medical attention and request blood tests.
Your AST and ALT levels are approximately 38 and 59 U/L, respectively.
Although the reference ranges may vary by laboratory, the general normal value is around 40 U/L, indicating that your hepatitis is not severe.
The treatment for hepatitis B involves antiviral medications, and the criteria for medication differ across regions such as the Americas, Europe, and Asia.
Therefore, it is advisable to discuss this with your gastroenterologist.

Additionally, you inquired about elevated cholesterol levels.
Cholesterol levels do not necessarily have a linear relationship with weight and BMI.
I recommend discussing further management with a metabolic specialist.
Thank you for your inquiry!

Reply Date: 2021/05/10

More Info


A cholesterol level of 254 mg/dL is considered high and may indicate an increased risk for cardiovascular diseases, including heart disease and stroke. However, the interpretation of this value is not straightforward and depends on several factors, including the levels of different types of cholesterol (LDL, HDL) and triglycerides, as well as your overall health, lifestyle, and family history.

Firstly, cholesterol is divided into different types: low-density lipoprotein (LDL), often referred to as "bad" cholesterol, and high-density lipoprotein (HDL), known as "good" cholesterol. LDL cholesterol contributes to the buildup of plaque in arteries, which can lead to atherosclerosis, while HDL cholesterol helps remove cholesterol from the bloodstream. Ideally, LDL levels should be less than 130 mg/dL, and HDL levels should be 60 mg/dL or higher. Unfortunately, your report does not provide these specific values, which are crucial for a comprehensive assessment.

Given your history of chronic hepatitis B, it is essential to consider how liver health may affect cholesterol levels. The liver plays a significant role in cholesterol metabolism, and liver diseases can lead to altered cholesterol levels. Your AST and ALT levels, which are liver enzymes, appear to be within normal limits, suggesting that your liver function is not severely compromised at this time. However, continuous monitoring is necessary, especially with a chronic condition like hepatitis B.

The fact that your doctor did not prescribe any cholesterol-lowering medication may be due to several reasons. They might have assessed your overall health, body weight, and lifestyle factors, concluding that immediate medication is not necessary. It is also possible that they are considering a more conservative approach, focusing on lifestyle modifications first. This is a common practice, especially for individuals who are not exhibiting other risk factors for heart disease, such as obesity, diabetes, or a family history of cardiovascular issues.

Lifestyle modifications can significantly impact cholesterol levels. Here are some recommendations:
1. Diet: Adopt a heart-healthy diet that includes plenty of fruits, vegetables, whole grains, and lean proteins. Limit saturated fats found in red meat and full-fat dairy products, and avoid trans fats found in many processed foods. Incorporating healthy fats, such as those from fish, nuts, and olive oil, can also be beneficial.

2. Exercise: Regular physical activity can help raise HDL cholesterol and lower LDL cholesterol. Aim for at least 150 minutes of moderate aerobic exercise each week, such as brisk walking or cycling.

3. Weight Management: Maintaining a healthy weight can help manage cholesterol levels. Even a modest weight loss can have a positive effect.

4. Avoid Tobacco and Limit Alcohol: Smoking can lower HDL cholesterol, and excessive alcohol consumption can lead to higher triglyceride levels.

5. Regular Monitoring: Since your cholesterol levels are elevated, it is essential to have regular check-ups to monitor your levels and assess any changes over time. Your doctor may recommend retesting your cholesterol levels in a few months to see if lifestyle changes have made a difference.

In conclusion, while a cholesterol level of 254 mg/dL is concerning, it does not automatically necessitate medication, especially if other risk factors are not present. It is crucial to engage in a healthy lifestyle and maintain regular follow-ups with your healthcare provider to monitor your cholesterol levels and liver health. If you have further concerns or if your symptoms persist, consider seeking a second opinion or consulting a specialist in lipid management or hepatology.

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