Schizophrenia: Seeking Medication for Guilt-Driven Delusions - Psychiatry

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Schizophrenia (Medication Consultation)


I previously sent you a message regarding my feelings of guilt and self-blame.
Despite the uncertainty of the situation, I have an overwhelming sense of energy that convinces me I have done something wrong.
I feel an intense need to compensate the car owner, or else I will continue to feel this guilt physically.
I cannot control this feeling, even after watching the surveillance footage 3000 times, which proves that I did not make a mistake at that time.
My body still believes I have done something terrible and that I deserve punishment, and I am unwavering in this belief.
I have asked other patients, and very few experience guilt-related delusions, so I am unsure how to seek help.
I previously took Sertraline for three weeks and Aripiprazole for two weeks, but I felt no effect.
Therefore, I would like to ask the doctor which medications are recommended for this type of delusion.

Hanhan, 20~29 year old female. Ask Date: 2021/05/14

Dr. Lin Mianzhang reply Psychiatry


Hello Han Han: For this type of delusion, if there are no accompanying symptoms of depression, anxiety, or obsessive-compulsive disorder, the primary treatment would still be antipsychotic medications.
If neither Seroquel (quetiapine) nor Abilify (aripiprazole) is effective, it may be due to insufficient dosage or lack of efficacy.
In this case, you can consider increasing the dosage or switching medications.
Generally, if two antipsychotic medications have been used at the maximum dosage without improvement, it is recommended to switch to clozapine, which is marketed under names such as Clozaril, Zapine, Clopine, and Uspen.
However, any adjustments to medication should be discussed and decided upon with your physician.
Wishing you peace and health.

Reply Date: 2021/05/14

More Info


Understanding and managing guilt-driven delusions in schizophrenia can be quite challenging, both for the individual experiencing these symptoms and for their healthcare providers. Guilt-driven delusions, where a person feels an overwhelming sense of guilt despite evidence to the contrary, can significantly impact daily functioning and quality of life.
In your case, it seems that you are experiencing persistent feelings of guilt related to an event where you believe you have wronged someone, despite having reviewed evidence that suggests otherwise. This type of delusion can be particularly distressing, as it creates a cycle of anxiety and self-blame that can be difficult to break.
From a medical perspective, antipsychotic medications are typically the first line of treatment for schizophrenia and related disorders. These medications work by altering the balance of neurotransmitters in the brain, particularly dopamine, which is often implicated in psychotic symptoms. Common antipsychotics include Seroquel (quetiapine), Risperdal (risperidone), and Abilify (aripiprazole). Each of these medications has a different side effect profile and mechanism of action, and their effectiveness can vary from person to person.

Given your previous experiences with medications like Sertraline (首利安) and Olanzapine (安立復), which did not yield the desired results, it may be beneficial to explore other options. Medications such as Clozapine (克拉氟平) are often considered for treatment-resistant cases of schizophrenia, but they require careful monitoring due to potential side effects.
In addition to medication, cognitive-behavioral therapy (CBT) can be an effective adjunct treatment for managing delusions and the associated feelings of guilt. CBT can help you develop coping strategies to challenge and reframe your thoughts, reducing the intensity of the guilt you feel. Working with a therapist who specializes in psychotic disorders can provide you with tools to manage these feelings more effectively.

It is also important to maintain open communication with your psychiatrist about your symptoms and any side effects you may be experiencing. If you feel that your current medication is not effective, or if you are struggling with side effects, do not hesitate to discuss this with your healthcare provider. They may suggest adjusting your dosage, switching medications, or adding a medication specifically aimed at addressing anxiety or mood symptoms that accompany your delusions.

Lastly, support groups for individuals with schizophrenia can be a valuable resource. Connecting with others who have similar experiences can provide emotional support and practical advice on managing symptoms.

In summary, addressing guilt-driven delusions in schizophrenia often requires a multifaceted approach that includes medication, therapy, and support. It is crucial to work closely with your healthcare provider to find the most effective treatment plan tailored to your specific needs. Remember, recovery is a journey, and with the right support and treatment, it is possible to manage these symptoms effectively.

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