Male Pattern Baldness: Genetics and Family Influence - Dermatology

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Regarding male pattern baldness inheritance?


Hello, I previously researched and learned from school that male pattern baldness is inherited in a sex-linked manner, and the information I found online also suggests that the genetic influence from the mother's side is usually greater for sons.
However, I am curious why there are still cases where both father and son experience baldness.
My father also has a baldness condition, so I hope to gain further understanding.
Thank you.

Verde, 10~19 year old female. Ask Date: 2021/06/02

Dr. Wu Yuxin reply Dermatology


Both parents can pass on genetic traits.

Reply Date: 2021/06/02

More Info


Male pattern baldness, also known as androgenetic alopecia, is a common condition that affects many men as they age. It is primarily influenced by genetics, and while it is often described as being inherited in a sex-linked manner, the reality is more complex.
The traditional understanding is that the gene responsible for male pattern baldness is located on the X chromosome, which men inherit from their mothers. This has led to the belief that maternal family history plays a significant role in determining whether a son will experience hair loss. However, recent research has shown that male pattern baldness is polygenic, meaning that multiple genes from both parents contribute to the likelihood of developing this condition.
In your case, since your father also experiences baldness, it is likely that you have inherited a combination of genetic factors from both your mother and father that predispose you to hair loss. The presence of baldness in your father suggests that there may be additional genetic influences at play, possibly from his side of the family as well.
Moreover, the expression of male pattern baldness can vary significantly among individuals, even within the same family. This variability can be attributed to the interaction of genetic predispositions with environmental factors, hormonal levels, and individual health. For instance, testosterone and its derivative dihydrotestosterone (DHT) play crucial roles in hair follicle miniaturization, which is a key process in male pattern baldness.
It's also important to note that while genetics is a significant factor, other elements such as stress, diet, and overall health can influence hair loss. Therefore, even if you have a family history of baldness, it does not guarantee that you will experience the same degree of hair loss as your father or any other male relatives.
If you are concerned about hair loss, it may be beneficial to consult with a dermatologist or a trichologist who specializes in hair and scalp health. They can provide insights into your specific situation and discuss potential treatments if necessary. Options may include topical treatments like minoxidil, oral medications like finasteride, or even hair transplant procedures, depending on the severity of the condition and your personal preferences.

In summary, while male pattern baldness is indeed influenced by genetics, it is not solely determined by maternal lineage. The interplay of multiple genes from both parents, along with environmental factors, contributes to the development of this condition. Understanding this complexity can help alleviate concerns and provide a clearer picture of what to expect regarding hair loss in the future.

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