Is One RU486 Pill Enough for Medical Abortion at Six Weeks? - Obstetrics and Gynecology

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Dosage of RU486


The dosage and number of RU486 (mifepristone) pills for medical abortion can vary.
In your case, you mentioned that you were given one pill after a confirmation of a 6-week pregnancy via ultrasound.
Generally, the standard dosage for medical abortion is three pills (600 mg total), taken under medical supervision.

If you only received one pill, it may not be sufficient for the intended effect.
However, it's important to follow your doctor's instructions, as they may have specific reasons for prescribing a different dosage based on your individual circumstances.
Regarding your symptoms after taking the first dose, experiencing bleeding with blood clots is common and can be similar to the second day of a regular menstrual period.
However, if you have concerns about the amount of bleeding or if you experience severe pain, fever, or other concerning symptoms, it is crucial to contact your healthcare provider for further evaluation and guidance.

DD, 40~49 year old female. Ask Date: 2021/06/09

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, you need to check the dosage of the medication you are taking.
If you experience significant bleeding after taking one pill, it indicates a strong reaction.
Please continue to follow up with your obstetrician-gynecologist.
Wishing you good health.

Reply Date: 2021/06/09

More Info


When it comes to medical abortion using RU486 (mifepristone), the standard protocol typically involves taking a dose of 200 mg of mifepristone, followed by a second medication, misoprostol (Cytotec), taken 24 to 48 hours later. The usual recommendation is to take either one or three pills of mifepristone, depending on the specific guidelines of the healthcare provider and the regulations in the region. In many cases, a single pill can be effective, but the three-pill regimen is often preferred for its higher efficacy rates.

In your situation, where you were prescribed only one pill of RU486 after confirming a six-week pregnancy, it is understandable to have concerns about whether this dosage is sufficient. Research indicates that a single dose of mifepristone can be effective in terminating a pregnancy, but the success rate may vary. The effectiveness of the medication can depend on several factors, including how far along the pregnancy is and individual physiological responses.

After taking RU486, it is common to experience bleeding, which can resemble a menstrual period. The presence of blood clots and a flow similar to the second day of a menstrual cycle is also typical. This bleeding is a sign that the body is responding to the medication, and it usually occurs within a few days after taking the first pill. However, if the bleeding becomes excessively heavy (soaking through two or more pads in an hour for two consecutive hours), or if you experience severe pain or other concerning symptoms, it is crucial to seek medical attention immediately.

In your case, since you mentioned that you have started bleeding and are passing blood clots, this could indicate that the medical abortion process is underway. However, it is essential to follow up with your healthcare provider to ensure that the abortion is complete and that there are no complications. A follow-up appointment is typically scheduled within a week or two after taking the medication to confirm that the pregnancy has been terminated successfully, often through ultrasound or blood tests to measure hormone levels.

If you have any concerns about the amount of bleeding or if you experience any unusual symptoms, such as fever, chills, or foul-smelling discharge, you should contact your healthcare provider for further evaluation. They may recommend additional treatment or monitoring to ensure your health and safety.

In summary, while one pill of RU486 can be sufficient for a medical abortion, it is essential to follow the guidance of your healthcare provider and to monitor your symptoms closely. If you have any doubts or experience any complications, do not hesitate to reach out for medical advice.

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