Your ENT Checkup Results: Key Insights on Nasopharyngeal Health - Otolaryngology

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Hello Doctor: My brother has a history of nasopharyngeal carcinoma, and my recent test results show: SCC (RIA) 0.77 EB VCA IgA 1.2 (+) EBNA Ab IgG 4.9 (+).
I would like to ask the doctor: 1.
Since both of my values are positive, does this mean I need to regularly monitor the condition of my nasopharynx? 2.
Should I be particularly concerned about the EBNA Ab IgG being significantly above the normal range? 3.
If the nasopharyngeal endoscopy shows no issues, is it sufficient to just have regular follow-ups? Thank you, doctor!

C, 20~29 year old female. Ask Date: 2021/06/18

Dr. Zheng Jueyi reply Otolaryngology


Hello: IgG generally indicates a past infection with the EBV virus, and its levels are not necessarily related to nasopharyngeal carcinoma.
However, if IgA is positive and there is a family history, it is recommended to have regular follow-ups with an otolaryngologist for monitoring of the nasopharynx.
Wishing you peace and health.
Sincerely, Dr.
Cheng Jue-Yi, Director of the Department of Otolaryngology, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2021/06/18

More Info


Understanding your ENT checkup results, especially in the context of a family history of nasopharyngeal cancer, is crucial for your health management. Based on the information you've provided, let's break down your concerns regarding the test results and what they might mean for your ongoing health monitoring.

1. Positive Results and Regular Monitoring: The presence of positive results for SCC (Squamous Cell Carcinoma) and EBV (Epstein-Barr Virus) antibodies indicates a need for careful monitoring. The SCC value of 0.77 suggests that there may be some abnormal cellular activity, which can be associated with malignancies, including nasopharyngeal carcinoma. Given your brother's history of nasopharyngeal cancer, it is prudent to follow up regularly with your ENT specialist. Regular check-ups may include physical examinations, imaging studies, and possibly repeat endoscopies to monitor for any changes in the nasopharyngeal area.

2. Elevated EBNA Ab IgG Levels: The EBNA Ab IgG level of 4.9, which is significantly above the normal range, indicates a past infection with EBV. While this is common, especially in individuals with a history of EBV exposure, it can also be associated with an increased risk of certain cancers, including nasopharyngeal carcinoma. However, elevated IgG levels alone do not confirm the presence of cancer; they simply indicate that your immune system has responded to the virus. It is essential to discuss the implications of this result with your healthcare provider, who may recommend further testing or monitoring based on your overall health and family history.

3. Endoscopy Results and Follow-Up: If your nasopharyngeal endoscopy results are normal, this is a positive sign. Normal findings during an endoscopy suggest that there are currently no visible lesions or abnormalities in the nasopharyngeal region. However, given your elevated SCC and EBV antibody levels, regular follow-up is still necessary. Your healthcare provider may suggest a schedule for follow-up appointments, which could range from every six months to annually, depending on your risk factors and any symptoms you may experience.

In summary, while your current test results warrant attention, they do not necessarily indicate an immediate cause for alarm. Regular monitoring and follow-up with your ENT specialist are essential components of managing your health, especially considering your family history. It is also important to maintain open communication with your healthcare provider about any new symptoms or concerns that may arise. Early detection and intervention are key in managing potential health issues effectively.
Additionally, lifestyle factors such as avoiding tobacco and excessive alcohol consumption, maintaining a healthy diet, and managing stress can also play a role in your overall health and may help reduce the risk of developing nasopharyngeal cancer. Always feel free to ask your healthcare provider any questions you may have about your results or health management strategies.

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