Best Over-the-Counter Fever Reducers for COVID Vaccine Recipients - Internal Medicine

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Purchase of antipyretics?


Hello, doctor.
I am allergic to anti-inflammatory medications such as ibuprofen and aspirin, which cause my eyes to swell.
I would like to know which type of fever reducer I can purchase at the pharmacy if I experience a fever after receiving the COVID-19 vaccine.
Thank you.

Dawei, 40~49 year old female. Ask Date: 2021/06/21

Dr. Hong Yuanbin reply Internal Medicine


Hello, based on your description, you may be allergic to non-steroidal anti-inflammatory drugs (NSAIDs).
Acetaminophen would be more suitable for you.
Thank you for your inquiry.

Reply Date: 2021/06/21

More Info


When considering over-the-counter (OTC) fever reducers for COVID-19 vaccine recipients, especially for individuals with known allergies to ibuprofen and aspirin (the active ingredients in common anti-inflammatory medications), it is essential to choose alternatives that are both effective and safe.
The most commonly recommended OTC fever reducers are acetaminophen (known as paracetamol in some countries). Acetaminophen is generally considered safe for most individuals, including those who are allergic to non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and aspirin. It works by inhibiting the production of prostaglandins in the brain, which helps to reduce fever and alleviate pain.
For someone who has allergies to ibuprofen and aspirin, acetaminophen is typically the first choice. It is available in various forms, including tablets, capsules, liquid suspensions, and effervescent formulations. The standard adult dosage is usually 500 mg to 1000 mg every 4 to 6 hours as needed, but it is crucial not to exceed the maximum daily limit of 3000 mg to 4000 mg, depending on the specific product and individual health considerations.
It is also important to note that while acetaminophen is effective for managing fever and discomfort, it does not have anti-inflammatory properties like NSAIDs. Therefore, if inflammation is a concern, other options may need to be considered in consultation with a healthcare provider.

In addition to acetaminophen, there are other alternatives that may be considered, but they should be approached with caution. For example, some people may consider using topical treatments or non-pharmacological methods such as cool compresses or hydration to help manage fever. However, these methods may not be as effective as systemic medications.

Before taking any medication, especially after receiving a vaccine, it is advisable to consult with a healthcare professional. They can provide personalized recommendations based on your medical history, current medications, and specific allergies. This is particularly important for individuals with a history of severe allergic reactions, as they may have unique considerations regarding medication safety.

Furthermore, it is worth mentioning that while fever is a common response to vaccination, it is generally a sign that the immune system is responding to the vaccine. Most vaccine-related fevers are mild and resolve on their own within a few days. If a fever is persistent or accompanied by severe symptoms, it is essential to seek medical attention.

In summary, for someone allergic to ibuprofen and aspirin, acetaminophen is the best OTC fever reducer to consider when preparing for a COVID-19 vaccination. Always consult with a healthcare provider for personalized advice, especially regarding medication choices and management of any potential side effects from the vaccine.

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