Can You Take Emergency Contraceptive Pills with GERD Medications on an Empty Stomach?

Can birth control pills be taken on an empty stomach along with medications for gastroesophageal reflux disease (GERD)?

Hello, doctor.
I am currently taking the emergency contraceptive pill, Ella (Ulipristal Acetate).
I would like to ask if it is safe to take this emergency contraceptive on an empty stomach along with medications for gastroesophageal reflux disease (GERD), which include MOPRIDE F.C.
5MG/TAB and NEXIUM 40MG/TAB.
Thank you, doctor!

Chen, 20~29 year old female. Ask Date: 2021/07/05

Dr. Zhang Kunmin reply Obstetrics and Gynecology

Hello,
Medications that may interact with oral contraceptives include:
1.
Antibiotics (Penicillin, Cephalosporins, Erythromycin, Sulfonamides, Bactrim, Chloramphenicol) - These may reduce the gut flora that aids in absorption, thereby decreasing the effectiveness of the contraceptive.
2.
Sedatives (Barbiturates) - These can increase the metabolism of oral contraceptives, reducing their effectiveness.
3.
Antiepileptic drugs (Primidone, Phenytoin, Carbamazepine) - These also increase the metabolism of oral contraceptives, leading to decreased effectiveness.
4.
Antituberculosis medications (Rifampicin, Isoniazid).
5.
Antidiabetic medications (Rosiglitazone).
6.
Acetaminophen and Ascorbic acid (Vitamin C) - These may inhibit the metabolism of estrogen, potentially increasing its concentration in the body and leading to a higher incidence of side effects.
7.
Oral contraceptives can affect the action of anticoagulants.
8.
Smoking - This can increase the metabolism of oral contraceptives, reducing their effectiveness.
The likelihood of interactions with the mentioned medications is relatively low.
Thank you! Wishing you peace and health.
Dr.
Zhang

Reply Date: 2021/07/05

More Info

When considering the use of emergency contraceptive pills (ECPs) alongside medications for gastroesophageal reflux disease (GERD), such as MOPRIDE (mosapride) and NEXIUM (esomeprazole), it is essential to understand how these medications interact and their effects on the gastrointestinal system.

Emergency contraceptive pills, like the one you mentioned (祈麗安), are designed to prevent pregnancy after unprotected intercourse. They are most effective when taken as soon as possible after the event, ideally within 72 hours. The effectiveness of ECPs can be influenced by various factors, including the timing of ingestion relative to meals and the presence of other medications.

MOPRIDE is a prokinetic agent that enhances gastrointestinal motility, which can help alleviate symptoms of GERD by promoting faster gastric emptying. NEXIUM, on the other hand, is a proton pump inhibitor (PPI) that reduces stomach acid production, providing relief from GERD symptoms by decreasing acid reflux into the esophagus.

Taking ECPs on an empty stomach is generally recommended to maximize absorption and effectiveness. However, when combined with GERD medications, there are a few considerations to keep in mind:
1. Timing and Absorption: Taking ECPs on an empty stomach can enhance their absorption. However, if you take them with or shortly after GERD medications, particularly PPIs like NEXIUM, there may be a slight delay in gastric emptying. This delay could theoretically affect the absorption of the ECPs, although the clinical significance of this interaction is not well-documented.

2. Potential Drug Interactions: While there are no significant direct interactions between ECPs and the GERD medications you mentioned, it is always prudent to consult with a healthcare provider. They can provide personalized advice based on your specific health situation and medication regimen.

3. Side Effects: Both ECPs and GERD medications can have gastrointestinal side effects. Taking them together may increase the likelihood of experiencing nausea, vomiting, or abdominal discomfort. If you experience any severe side effects, it is important to seek medical attention.

4. Consultation with Healthcare Provider: Given your specific circumstances, including the medications you are taking for GERD, it is advisable to discuss your situation with a healthcare provider. They can offer tailored advice and ensure that you are using the medications safely and effectively.

In summary, while it is generally acceptable to take emergency contraceptive pills with GERD medications, doing so on an empty stomach is preferable for optimal absorption. However, consulting with a healthcare provider is crucial to address any potential interactions and to ensure that your overall treatment plan is safe and effective. Always prioritize your health and well-being by seeking professional guidance when managing multiple medications.

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