the Use of Xylometazoline for Allergic Rhinitis Relief - Internal Medicine

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The medication commonly prescribed by otolaryngologists is Xylometazoline?


I have mostly experienced nasal congestion or discomfort in my nose over the past few years, which is why I sought medical attention, unlike before when I primarily went to the doctor for a runny nose and nasal blockage.
If I have been prescribed medication like Xylometazoline, should I finish the entire course, or what should I do? I am a patient with allergic rhinitis, but I usually seek medical help because of the uncomfortable feeling in my nose, which seems related to breathing difficulties.
I wonder what the doctor's opinion is on this matter.

yi, 40~49 year old female. Ask Date: 2021/07/06

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your message.
Xylo is a combination medication, one of its components causes vasoconstriction of the nasal mucosa, which can relieve your nasal congestion or stuffiness.
However, this component may occasionally cause palpitations as a side effect, and prolonged use can lead to diminished effectiveness.
It is recommended that you use it only when you experience symptoms.
Best regards from the Department of Allergy, Immunology, and Rheumatology at Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2021/07/06

More Info


Xylometazoline is a commonly used nasal decongestant that provides relief for individuals suffering from allergic rhinitis and nasal congestion. It works by constricting the blood vessels in the nasal passages, leading to reduced swelling and congestion, allowing for easier breathing. However, it is crucial to understand the implications of long-term use of this medication.

The primary concern with prolonged use of Xylometazoline is the risk of developing rhinitis medicamentosa, a condition characterized by rebound nasal congestion. When Xylometazoline is used for more than the recommended duration (typically no more than 7-10 days), the nasal mucosa can become dependent on the medication. As a result, when the medication is discontinued, the nasal passages may swell even more than before, leading to a cycle of dependency where the user feels compelled to continue using the spray to alleviate the congestion caused by the rebound effect.

In your case, where you have been experiencing discomfort in your nasal passages without significant nasal discharge, it is essential to evaluate the underlying causes of your symptoms. Allergic rhinitis can manifest in various ways, including nasal congestion, sneezing, itching, and post-nasal drip. If your primary symptom is a feeling of discomfort or difficulty breathing through your nose, it may be beneficial to explore other treatment options that address the root cause of your allergies rather than relying solely on Xylometazoline.

For individuals with allergic rhinitis, antihistamines (such as cetirizine or loratadine) can be effective in managing symptoms. These medications work by blocking the action of histamine, a substance in the body that causes allergic symptoms. Additionally, intranasal corticosteroids (like fluticasone or mometasone) are often recommended as a first-line treatment for allergic rhinitis. They help reduce inflammation in the nasal passages and can provide long-term relief without the risk of rebound congestion associated with decongestants.

If you find that your symptoms persist despite using Xylometazoline or other medications, it may be worthwhile to consult with an allergist or an ear, nose, and throat (ENT) specialist. They can perform a thorough evaluation, including allergy testing, to identify specific triggers for your symptoms and recommend a tailored treatment plan. This may include allergen avoidance strategies, immunotherapy (allergy shots), or other medications that can provide more sustainable relief.

In summary, while Xylometazoline can offer temporary relief from nasal congestion, its long-term use is not advisable due to the risk of rebound congestion and dependency. Exploring alternative treatments, such as antihistamines and intranasal corticosteroids, may provide more effective and safer management of your allergic rhinitis symptoms. Always consult with a healthcare professional before making changes to your medication regimen to ensure that you receive the most appropriate care for your condition.

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